戴文砚,王可可,王金华.外泌体microRNAs在卵巢癌诊断和治疗中作用的研究进展[J].肿瘤学杂志,2023,29(1):19-23. |
外泌体microRNAs在卵巢癌诊断和治疗中作用的研究进展 |
Research Progress on Exosomal microRNAs in the Diagnosis and Treatment of Ovarian Cancer |
投稿时间:2022-11-01 |
DOI:10.11735/j.issn.1671-170X.2023.01.B004 |
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中文关键词: 外泌体 microRNAs 卵巢癌 诊断 治疗 发病机制 |
英文关键词:exosomal microRNAs ovarian cancer diagnosis treatment pathogenesis |
基金项目:江苏省医学重点人才(2016KJQWZDRC-02) |
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中文摘要: |
摘 要:外泌体microRNAs(miRNAs)在卵巢癌进展的各种过程中发挥重要作用,如卵巢癌细胞增殖、凋亡和侵袭。外泌体miRNAs通过各种途径参与基因表达、信使RNA合成、蛋白生成等,有助于对卵巢癌发病机制的理解。由于miRNAs在血浆外泌体中的有效性,miRNAs可作为新兴的癌症早期检测和治疗评估生物标志物。外泌体miRNAs作为一种信使,在肿瘤微环境中起着重要的作用,越来越多的研究也证实了miRNAs作为靶点治疗卵巢癌的可行性。 |
英文摘要: |
Abstract: Exosomal microRNAs(miRNAs) play an important role in various processes of ovarian cancer progression, such as ovarian cancer cell proliferation, apoptosis and invasion. Exosomal miRNAs are involved in gene expression, message RNA(mRNA) synthesis and protein generation through various pathways, and as a messenger, exosomal miRNAs take a significant role in tumor microenvironment, all these contribute our understanding of the pathogenesis of ovarian cancer. A growing number of studies have shown that miRNAs as emerging biomarkers can be used for early detection and treatment evaluation, and also as targets for treatment of ovarian cancer. |
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