| 刘娟妮,李俊海,吴宏培.循环肿瘤细胞联合血清CA153检测在转移性乳腺癌中临床意义[J].肿瘤学杂志,2021,27(3):202-205. |
| 循环肿瘤细胞联合血清CA153检测在转移性乳腺癌中临床意义 |
| Clinical Significance of Circulating Tumor Cells and CA153 Detection in Patients with Metastatic Breast Cancer |
| 投稿时间：2020-02-03 |
| DOI：10.11735/j.issn.1671-170X.2021.03.B009 |
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| 中文关键词: 转移性乳腺癌 循环肿瘤细胞 糖类抗原153 |
| 英文关键词:metastatic breast cancer circulating tumor cells carbohydrate antigen 153 |
| 基金项目:陕西省自然科学基础研究计划项目（2014JM4109） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨循环肿瘤细胞(CTCs)和肿瘤标志物CA153检测在转移性乳腺癌(MBC)中临床意义。［方法］ 选取2016年5月至2018年5月诊治的80例转移性乳腺癌患者作为研究对象，患者均给予化疗、靶向或内分泌治疗等，检测治疗前后CTCs和肿瘤标志物CA153水平，分析其与疗效及预后的关系。［结果］ MBC治疗后CTCs阳性率（37.50%）明显低于治疗前（61.25%）（P<0.05）；治疗后糖类抗原153（CA153）低于治疗前，但差异无统计学意义（P>0.05）。80例MBC患者治疗后达到完全或部分缓解30例(37.5%)，稳定27例(33.75%)，无效进展23例(28.75%)。患者病程中CTCs数目的改变与病情的转归相关。化疗后CTCs数目不变或下降的病例，预后较好；化疗后CTCs数目上升的病例预后差。［结论］ 循环肿瘤细胞联合血清CA153检测能够预测疗效和判断预后。循环肿瘤细胞在监测转移性乳腺癌疗效和预后具有一定的临床价值。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the clinical significance of circulating tumor cells(CTCs) and carbohydrate antigen 153(CA153) detection in metastatic breast cancer patients(MBC). ［Methods］ Eighty cases of metastatic breast cancer which were treated in our hospital from May 2016 to May 2018 were selected. All the patients were given chemotherapy，targeted therapy and endocrine therapy and so on. The changes of CTCs and CA153 in peripheral blood before and after treatment were detected to monitor the efficacy，and the relationship between CTCs and the curative effect and prognosis was analyzed. ［Results］ The positive rate of CTCs after treatment(37.50%) was significantly lower than that before treatment（61.25%）(P<0.05). The levels of CA153 after treatment were lower than those of before treatment，but the difference was not statistically(P>0.05). Among the 80 patients，30 cases achieved complete or partial remission(37.5%)，27 cases remained stable(33.75%)，and 23 cases were regressive(28.75%). Changes in CTCs numbers were significantly associated with the disease progresses after chemotherapy. ［Conclusion］ The detection of circulating tumor cells and CA153 in peripheral blood can evaluate curative effect and prognosis of patients with metastatic breast cancer. Circulating tumor cells were more sensitive in monitoring the efficacy and prognosis of metastatic breast cancer，it has a certain clinical value and was worth to be popularized. |
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