| 蔡静静,吴茂芳,莫 欣.环状RNA在恶性肿瘤耐药中的研究进展[J].肿瘤学杂志,2020,26(9):822-825. |
| 环状RNA在恶性肿瘤耐药中的研究进展 |
| Progress on CircularRNA in Drug Resistance of Malignant Tumors |
| 投稿时间：2019-09-23 |
| DOI：10.11735/j.issn.1671-170X.2020.09.B014 |
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| 中文关键词: 环状RNA 癌症 耐药 药物疗法 |
| 英文关键词:circRNA cancer resistant drug therapy |
| 基金项目:国家自然科学基金资助项目（81860513）；云南省科技计划资助项目(2017FA037、2016FB145） |
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| 中文摘要: |
| 摘 要：环状RNA作为体内稳定存在的一种非编码RNA广受关注，其不仅参与肿瘤发生发展，也与化疗耐药密切相关。全文主要关注环状RNA在恶性肿瘤化疗耐药中的作用，旨在深入探究耐药可能的分子机制，为临床肿瘤治疗提供有希望的潜在靶点。 |
| 英文摘要: |
| Abstract：Chemotherapy is one of the most effective methods for treatment of malignant tumors，but tumor cells can develop resistance to multiple drugs during the therapy，leading to treatment failure. In recent years，circular RNA has attracted much attention as a non-coding RNA stably present in vivo. Accumulating evidences suggest that circRNAs play a critical role in the occurrence and development of various types of cancer，as well as in chemotherapy resistance. In this review，we summarize the role of circRNAs in the resistance of tumors to chemotherapy，aiming to explore the specific molecular mechanisms and to provide potential targets for drug resistance in cancer treatment. |
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