| 周 园,杜丽辉,张 娟.宫颈癌组织中YB-1、miR-29a、Nek2的表达与细胞增殖、侵袭基因的相关性[J].肿瘤学杂志,2020,26(3):190-193. |
| 宫颈癌组织中YB-1、miR-29a、Nek2的表达与细胞增殖、侵袭基因的相关性 |
| Expression of YB-1，miR-29a and Nek2 in Cervical Cancer and Its Relation with Cell Proliferation and Invasion |
| 投稿时间：2019-10-23 |
| DOI：10.11735/j.issn.1671-170X.2020.03.B005 |
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| 中文关键词: 宫颈癌 细胞增殖 细胞侵袭 |
| 英文关键词:cervical cancer cell proliferation cell invasion |
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| 中文摘要: |
| 摘 要：［目的］ 评价宫颈癌组织中YB-1、miR-29a、Nek2表达与细胞增殖、侵袭基因的相关性。［方法］ 选取2017年1月至2018年1月我院收治的宫颈癌患者60例，取宫颈癌患者手术切除癌组织及癌旁组织标本，检测癌组织、癌旁组织中YB-1、miR-29a、Nek2、细胞增殖基因和细胞侵袭基因表达情况。［结果］ 癌组织中YB-1 mRNA、Nek2 mRNA表达量为（1.52±0.36、1.96±0.35）高于癌旁组织（1.00±0.10、1.00±0.13），miR-29a mRNA表达量为（0.98±0.10）低于癌旁组织（1.06±0.23）（P均<0.05）。癌组织细胞增殖基因YAP1 mRNA、Piwil2 mRNA、EZH2 mRNA、PKCε mRNA表达量高于癌旁组织（P均<0.05）。癌组织细胞侵袭基因Rab11 mRNA、TUG1 mRNA、Gli1 mRNA、FoxM1 mRNA表达量高于癌旁组织（P均<0.05）。［结论］ YB-1、Nek2在宫颈癌组织中高表达，miR-29a在宫颈癌组织中低表达，且与癌细胞增殖、侵袭基因相关，其表达异常可促进细胞增殖、侵袭。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of YB-1，miR-29a，Nek2 in cervical cancer and its relation with cell proliferation and invasion. ［Methods］ Sixty patients with cervical cancer admitted to our hospital from January 2017 to January 2018 were recruited. The mRNA expression of cell proliferation-related genes YAP1，Piwil2，EZH2，PKCε and cell invasive related-genes Rab11，TUG1，Gli1，FoxM1 in cancer tissues and adjacent tissues were detected by RT-PCR. ［Results］ The expression of YB-1 mRNA and Nek2 mRNA in cancer tissues was higher than that in adjacent tissues，and the expression of miR-29a mRNA was lower than that in adjacent tissues(P all<0.05 ). The expression levels of Yap1 mRNA，PIWIL2 mRNA，EZH2 mRNA and PKC ε mRNA in cancer tissue were higher than that in adjacent tissue(all P<0.05). The expression levels of Rab11 mRNA，tug1 mRNA，Gli1 mRNA and FoxM1 mRNA in cancer tissues were higher than those in adjacent tissues(P all<0.05). ［Conclusion］ Cell proliferation and invasion genes YB-1 and Nek2 are highly expressed，miR-29a is low expressed in cervical cancer，which can promote cell proliferation and invasion. |
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