| 魏 东,薛志芳,刘 博.PDGF-B、PDGFR-α在pN0期NSCLC癌组织中的表达及意义[J].肿瘤学杂志,2020,26(1):35-38. |
| PDGF-B、PDGFR-α在pN0期NSCLC癌组织中的表达及意义 |
| Expression of PDGF-B and PDGFR-α in pN0 Stage NSCLC and Their Significance |
| 投稿时间：2019-05-31 |
| DOI：10.11735/j.issn.1671-170X.2020.01.B008 |
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| 中文关键词: 血小板衍生生长因子 非小细胞肺癌 免疫组化染色 淋巴结微转移 |
| 英文关键词:platelet-derived growth factor non-small cell lung cancer immunohistochemical staining lymph node micrometastasis |
| 基金项目:张家口市科技攻关计划项目(13201047D) |
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| 中文摘要: |
| 摘 要：［目的］ 研究血小板衍生生长因子-B(PDGF-B)、血小板衍生生长因子受体-α（PDGFR-α）在pN0期非小细胞肺癌(NSCLC)癌组织中的表达及意义。［方法］ 选取2013年3月至2014年3月在我院进行根治性肺叶切除手术pN0期的NSCLC患者50例。取所有患者手术切除癌组织标本以及与癌组织距离5cm以上的癌旁正常肺组织制作标本，免疫组化处理后检测PDGF-B、PDGFR-α表达，并进行相关性分析。［结果］ 癌组织中PDGF-B阳性表达率（96.00%）高于癌旁组织（40.00%）；癌组织中PDGFR-α阳性表达率（92.00%）高于癌旁组织（40.00%）（P＜0.05）。NSCLC患者PDGF-B、PDGFR-α阳性表达率与性别、年龄无关，与吸烟史、肿瘤体积、组织学类型、病理分级以及淋巴结转移有关。有吸烟史、肿瘤体积较大、病理分级较高以及淋巴结微转移的患者PDGF-B、PDGFR-α阳性表达率较高（P＜0.05）。［结论］ PDGF-B、PDGFR-α参与pN0期非小细胞肺癌的发生与发展，在癌组织中的阳性表达率较高。对临床上pN0期非小细胞肺癌的诊断有着重要的意义。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression and significance of platelet-derived growth factor-B(PDGF-B) and platelet-derived growth factor-α(PDGFR-α) in pN0 stage non-small cell lung cancer(NSCLC). ［Methods］ Fifty patients with pN0 stage NSCLC underwent radical lobectomy from March 2013 to March 2014. The specimens of cancer tissue and adjacent lung tissue were taken，and the expression of PDGF-B and PDGFR-α were detected by immunohistochemical staining，enzyme-linked immunosorbent assay and immunoturbidimetric assay. The correlation between PDGF-B and PDGFR-α expressions was analyzed. ［Results］ The positive expression rates of PDGF-B and PDGFR-α were higher than those in adjacent tissues(96.00% vs 40.00%，92.00% vs 40.00%，respectively both P<0.05).The positive expression rates of PDGF-B and PDGFR-α in NSCLC patients were not correlated with sex and age，but correlated with smoking history，tumor volume，histological type，pathological grade and lymph node metastasis(all P<0.05). ［Conclusion］ The expression of PDGF-B and PDGFR-α are up-regulated in pN0 non-small cell lung cancer，which may be involved in the occurrence and development of NSCLC. |
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