| 谭祖稳,吴梦雪,黄 鑫.抗肿瘤多肽GE11及其应用研究进展[J].肿瘤学杂志,2019,25(10):900-903. |
| 抗肿瘤多肽GE11及其应用研究进展 |
| Research Advances on Antineoplastic Peptide GE11 and Its Application |
| 投稿时间：2018-07-12 |
| DOI：10.11735/j.issn.1671-170X.2019.10.B010 |
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| 中文关键词: 靶向治疗 小分子多肽 GE11 EGFR |
| 英文关键词:targeting therapy small molecular peptide GE11 EGFR |
| 基金项目:重庆市自然科学基金计划项目（cstc2014jcyja10012） |
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| 中文摘要: |
| 摘 要：自肿瘤靶向治疗成为手术、化疗和放疗等方法外的又一新的抗癌策略，国内外出现了多种靶向药物。较EGFR-TKI、单克隆抗体，多肽具有对靶蛋白亲和性高、分子量小、免疫原性低、易于合成和修饰等优点，其中，小分子多肽GE11的应用最为广泛。GE11可以特异性结合并作用于高表达EGFR的肿瘤组织，与肿瘤生长转移相关的信号转导分子相互作用，从而达到显像或者治疗目的。全文就抗肿瘤多肽GE11的作用机制、合成方法、临床科研中的应用进展等进行概述。 |
| 英文摘要: |
| Abstract：Since tumor targeting therapy became a new anticancer strategy，a variety of targeted drugs have developed at home and abroad. Compared with EGFR-TKI and monoclonal antibodies，peptides have the advantages of high affinity to target protein，low molecular weight，low immunogenicity，and they are also easy to be synthesized and modified. Among them，the small molecular peptide GE11 is most widely used. GE11 can specifically bind on tumor tissues with high expression of EGFR，and interact with signal transduction molecules related to tumor growth and metastasis，which can be used for cancer imaging or therapy. The progress on the mechanism，synthetic method，clinical application of antineoplastic peptide GE11 is summarized in this article. |
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