| 闫其星,罗静茹,李永富.VEGFA基因多态性与晚期非小细胞肺癌含铂方案近期疗效的相关性[J].肿瘤学杂志,2019,25(9):783-787. |
| VEGFA基因多态性与晚期非小细胞肺癌含铂方案近期疗效的相关性 |
| Association of VEGFA Gene Polymorphisms with Response of Platinum-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer |
| 投稿时间：2019-05-03 |
| DOI：10.11735/j.issn.1671-170X.2019.09.B004 |
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| 中文关键词: 血管内皮生长因子A 单核苷酸多态性 非小细胞肺癌 疗效 |
| 英文关键词:vascular endothelial growth factor A single nucleotide polymorphisms non-small cell lung cancer chemotherapeutic response |
| 基金项目:海南省科技厅重点项目(ZDYF2017133) |
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| 中文摘要: |
| 摘 要：［目的］ 探讨VEGFA rs699947与rs833069位点的单核苷酸多态性与晚期非小细胞肺癌含铂方案近期疗效的关系。［方法］ 收集经病理确诊、驱动基因阴性且接受含铂方案化疗的晚期非小细胞肺癌患者95例及其临床资料，采集静脉血标本，提取血液基因组DNA，高通量测序鉴定rs699947和rs833069位点的基因型，分析各基因型与近期疗效之间的相关性。［结果］ 95例晚期非小细胞肺癌患者中25例（26.3%）评估为部分缓解，70例（73.7%）为稳定或进展。近期疗效与性别、年龄、吸烟状态、ECOG评分、病理类型、组织分化程度、临床分期、淋巴结转移、远处转移、化疗方案以及rs833069位点的单核苷酸多态性无关（P＞0.05），与rs699947位点的单核苷酸多态性相关（P=0.044）。携带CC基因型患者的部分缓解率为37%（17/46），显著性高于携带AA或AC基因型患者的16.3%（8/49）（OR=0.333，95%CI：0.127~0.874；P=0.022）。［结论］ VEGFA rs699947位点的单核苷酸多态性与驱动基因阴性的晚期非小细胞肺癌患者的近期疗效有关，rs699947 CC基因型可能是对含铂方案敏感的分子标志物。 |
| 英文摘要: |
| Abstract：［Objective］ To evaluate the association between the polymorphisms in VEGFA rs699947/rs833069 and the response of platinum-based chemotherapy in advanced non-small cell lung cancer. ［Methods］ 95 cases with pathologically confirmed whose driver gene was negative and received platinum-based chemotherapy. Genomic DNA was extracted using a blood genome extraction kit. Single nucleotide polymorphism of rs699947/rs833069 was conducted using high-throughout sequencing technology，and the relationship between the genotypes and chemotherapeutic response was analyzed by logistic regression. ［Results］ 25 patients were partial remission(26.3%) and 70 patients were stable or progressive(73.7%) in 95 advanced non-small cell lung cancer. The chemotherapeutic response was unrelated with gender，age，smoking status，ECOG，histology，differentiation，stage，lymphatic metastasis，distant metastasis，chemotherapy program and the genotypes of VEGFA rs833069(P＞0.05). The genotypes of rs699947 were related with the chemotherapeutic response(P=0.044). The partial remission rate of CC genotype was 37%(17/46)，which was higher than the individuals with AA and AC genotypes with partial remission rate of 16.3%(8/49)(OR=0.333，95%CI：0.127~0.874，P=0.022）. ［Conclusion］ The polymorphisms of VEGFA rs699947 are associated with the chemotherapeutic response of advanced non-small cell lung cancer， and rs699947 CC genotype may be a predictor for which received platinum-based chemotherapy. |
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