陈进宝,邱艳艳,殷佩浩.外泌体在肿瘤化疗耐药与转移中作用研究进展[J].肿瘤学杂志,2019,25(7):658-662. |
外泌体在肿瘤化疗耐药与转移中作用研究进展 |
Research Progress on Exosomes in Tumor Chemotherapy Resistance and Tumor Metastasis |
投稿时间:2018-11-30 |
DOI:10.11735/j.issn.1671-170X.2019.07.B015 |
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中文关键词: 外泌体 肿瘤 耐药 转移 |
英文关键词:exosomes tumor drug resistances metastasis |
基金项目:国家自然科学基金面上项目(81873137);国家自然基金青年科学基金项目(81603464);上海市科委2016年度医学引导类(中、西医)科技支撑项目(16411972600) |
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中文摘要: |
摘 要:外泌体是一种由绝大多数细胞释放的、具有脂质双分子层和丰富内容物的微囊泡结构。近年来发现外泌体中不仅包含功能性蛋白,还有功能性核酸物质,这些蛋白质和核酸等在调节肿瘤微环境、促进细胞间通讯、促进肿瘤耐药与侵袭转移方面起了关键作用,参与肿瘤进程。全文主要总结了国内外有关外泌体在肿瘤化疗耐药与转移方面的研究进展,以更好地了解外泌体在促进肿瘤耐药和转移的相关机制。 |
英文摘要: |
Abstract:Exosomes are microvesicle of 30~100nm in diameter with a lipid bilayer and abundant contents that are released by most of cells. In recent years,it has been found that exosomes contain not only functional proteins,but also functional nucleic acids. These proteins and nucleic acids play a key role in regulating tumor microenvironment,promoting cell communication,participating in drug resistance,tumor invasion and metastasis,and therefore are involved in tumor progression. This article summarizes the research progress of roles of exosomes in tumor chemotherapy resistance and metastasis,as well as the relevant mechanisms. |
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