| 胡小凤,方醒艺,朱 蕾.PSMD4蛋白在上皮性卵巢癌中表达及意义[J].肿瘤学杂志,2019,25(7):603-606. |
| PSMD4蛋白在上皮性卵巢癌中表达及意义 |
| Expression of PSMD4 in Epithelial Ovarian Cancer and Its Significance |
| 投稿时间：2019-03-21 |
| DOI：10.11735/j.issn.1671-170X.2019.07.B003 |
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| 中文关键词: 上皮性卵巢癌 PSMD4蛋白 免疫组织化学 |
| 英文关键词:epithelial ovarian cancer PSMD4 immunohistochemistry |
| 基金项目:云南省卫生科技计划项目（2017NS188） |
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| 摘要点击次数: 1935 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨上皮性卵巢癌中PSMD4表达及意义。［方法］ 回顾性分析2013年1月至2017年12月在昆明医科大学第三附属医院（云南省肿瘤医院）接受诊治的上皮性卵巢癌患者101例，用免疫组化法检测上皮性卵巢癌组织中PSMD4表达，并以40例正常卵巢上皮作为对照；分析PSMD4表达与患者临床病理参数及预后的关系。［结果］ 相比正常卵巢上皮，上皮性卵巢癌组织中PSMD4高表达 (P=0.001)。PSMD4表达与卵巢癌患者年龄、淋巴结转移、治疗前CA125及是否双侧患病无关(P>0.05)，但PSMD4低表达组肿瘤分化程度较好(P=0.042）。至随访结束，失访2例，在访99例中51例（51.5%）复发，PSMD4高表达组复发率明显高于PSMD4低表达组（P=0.020）；PSMD4低表达组的无铂间期为（26.26±9.06）个月，较PSMD4高表达组[（22.91±6.95）个月]延长约3.5个月（P=0.042）；但PSMD4表达程度与是否耐药复发无关（P>0.05）。Kaplan-Meier生存分析提示，PSMD4高表达是无进展生存期的不良影响因素（P=0.039）。［结论］ PSMD4蛋白在上皮性卵巢癌组织中表达上调；PSMD4高表达与肿瘤分化不良以及肿瘤复发相关，且是PFS不良影响因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression and significance of PSMD4(26s proteasome non-ATPase regulated subunit 4) in epithelial ovarian cancer. ［Methods］ Retrospective analysis was performed on 101 cases of epithelial ovarian cancer patients who were diagnosed and treated in The Third Affiliated Hospital of Kunming Medical University，Yunnan Provincial Tumor Hospital from January 2013 to December 2017. Immunohistochemistry was used to detect the expression of PSMD4 in epithelial ovarian cancer tissue，and 40 samples of normal ovarian cortex were used as the control group. The relationship between PSMD4 expression and the clinicopathological parameters and prognosis of patients were analyzed. ［Results］ The high-expression rate of PSMD4 in epithelial ovarian cancer tissue was higher than that in normal ovarian cortex(P=0.001). The expression of PSMD4 was negatively correlated with tumor differentiation(P=0.042)，but was not correlated with age，lymph node metastasis，pretreatment CA125 level，unilateral or bilateral disease(P>0.05). Ninety nine patients were followed-up，and 51(51.5%) had recurrence. The recurrence rate of patients with PSMD4 high-expression was significantly higher than that with low PSMD4 expression(P=0.020). The platinum free interval of patients with PSMD4 low-expression(26.26±9.06 months) was significantly longer than that of patients with PSMD4 high-expression(22.91±6.95 months)(P=0.042). Kaplan-Meier survival analysis suggested that high-expression of PSMD4 was associated with poorer progression free survival in patients(P=0.039). ［Conclusion］ PSMD4 protein is up-regulated in epithelial ovarian cancer. High expression of PSMD4 is associated with poor tumor differentiation and tumor recurrence，and is an adverse influence factor of PFS in patients with epithelial ovarian cancer. |
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