| 张海燕,李 迅.维吾尔族霍奇金淋巴瘤与HLA-DPA1、DPB1基因多态性的相关性分析[J].肿瘤学杂志,2018,24(12):1186-1190. |
| 维吾尔族霍奇金淋巴瘤与HLA-DPA1、DPB1基因多态性的相关性分析 |
| Relationship of HLA-DPA1，DPB1 Gene Polymorphisms with Hodgkin’s Lymphoma in Uyghur Population |
| 投稿时间：2017-10-16 |
| DOI：10.11735/j.issn.1671-170X.2018.12.B009 |
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| 中文关键词: 霍奇金淋巴瘤 维吾尔族 人类白细胞抗原 基因频率 |
| 英文关键词:Hodgkin’s lymphoma Uygur human leukocyte antigen gene frequency |
| 基金项目:新疆自治区优秀青年科技创新人才培养项目（2014721044） |
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| 中文摘要: |
| 摘 要：［目的］ 研究人类白细胞抗原（human leukocyte antigen，HLA）DPA1、DPB1基因多态性与维吾尔族霍奇金淋巴瘤（Hodgkin’s lymphoma，HL）遗传易感性的关系。［方法］ 采用DNA直接测序分型（sequence based typing，SBT）法，检测40例维吾尔族HL患者和80名健康体检者的DPA1、DPB1基因多态性，对两组间的HLA-DPA1、DPB1等位基因频率进行统计分析。［结果］ （1）病例组分别检出3、10个低分辨等位基因型，对照组中分别检出3、9个低分辨等位基因型，HLA-DPA1、DPB1基因座位上等位基因频率分布均满足Hardy-Weninberg遗传平衡检验(P>0.05)。（2）维吾尔族HL患者中HLA-DPA1*03，DPB1*57，DPA1*01-DPB1*05，DPA1*01-DPB1*57，DPA1*02-DPB1*05，DPA1*02-DPB1*57，DPA1*03-DPB1*05 基因频率明显高于健康对照组，差异均有统计学意义（P<0.05）。［结论］ HLA-DPA1、DPB1基因与维吾尔族人群的HL发生密切相关。 |
| 英文摘要: |
| Abstract：［Objective］ To examine the association of human leukocyte antigen(HLA) DPA1，DPB1 gene polymorphisms with Hodgkin’s lymphoma(HL) in Uyghur patients. ［Methods］ The DPA1，DPB1 gene polymorphisms in 40 Uyghur HL patients and 80 healthy controls were detected by DNA direct sequencing classification(SBT) method. The allele frequency of HLA-DPA1，DPB1 in two groups were analyzed. ［Results］ There were 3 and 10 types of low resolution alleles of HLA-DPA1 and DPB1 gens in HL group，and 3 and 9 types of low resolution alleles in control group，respectively. HLA-DPA1，DPB1 gene seat waiting for a frequency distribution met the Hardy-Weninberg genetic balance test(P>0.05). The frequencies of HLA-DPA1*03，DPB1*05，DPB1*57，DPA1*01-DPB1*05，DPA1*01-DPB1*57，DPA1*02-DPB1*05，DPA1*02-DPB1*57 and DPA1*03- DPB1*05 genotypes in HL Uyghur patients were significantly higher than those in Uygur healthy controls(P<0.05). ［Conclusions］ HLA-DPA1，DPB1 gene may be associated with HL in Uyghur patients. |
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