| 吴刚峰,任 煜,林标扬.尿液代谢组学筛选膀胱癌代谢标志物研究进展[J].肿瘤学杂志,2018,24(10):1014-1018. |
| 尿液代谢组学筛选膀胱癌代谢标志物研究进展 |
| The Progress of Bladder Cancer Metabolic Markers Discovery Using Urinary Metabonomics |
| 投稿时间：2017-06-02 |
| DOI：10.11735/j.issn.1671-170X.2018.10.B015 |
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| 中文关键词: 膀胱肿瘤 尿液代谢组学 代谢标志物 |
| 英文关键词:bladder cancer urine metabonomics metabolic markers |
| 基金项目:绍兴市公益性技术应用研究计划 (2014B70080) |
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| 摘要点击次数: 1708 |
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| 中文摘要: |
| 摘 要：膀胱癌是泌尿生殖系统常见的恶性肿瘤之一，其具有高进展率、高发病率和死亡率以及高复发率特征。目前，针对膀胱癌早期诊断和预后监督缺乏有效的生物标志物。代谢组学作为系统生物学重要分支之一，尿液代谢组学在膀胱癌生物标志物筛选和鉴定等方面具有显著的优势。已有大量文献研究报道了尿液代谢组学在膀胱癌中应用，并在尿液中筛选发现20多种膀胱癌代谢标志物。全文根据目前尿液代谢组学在膀胱癌中的研究进展，对尿液代谢组学以及发现的膀胱癌代谢标志物嘌呤与嘧啶、色氨酸、马尿酸、肉毒碱类和牛磺酸等进行综述。 |
| 英文摘要: |
| Abstract：Bladder cancer(BC) is one of the most common malignant cancers of genitourinary system worldwide，with high progression，recurrence，morbidity and mortality rates. However，there is no effective biomarkers for early diagnosis and prognosis monitoring of bladder cancer at present. Metabonomics，as one of the important branches of systems biology，has significant advantages over the screening and identification of bladder cancer biomarkers. In recent years，a large number of studies have reported the application of urine metabonomics in the research of bladder cancer，and more than 20 metabolic markers of have been confirmed in the urine. The current progress of urine metabonomics and bladder cancer metabolic markers，including purine and pyrimidine metabolism，tryptophan metabolism，hippuric acid，carnitine species，taurine and so on were reviewed in this paper. |
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