| 中文关键词: 环状 RNA 非编码RNA 微小RNA海绵 肿瘤 |
| 英文关键词:circular RNA non-coding RNA micro RNA sponge tumor |
| 基金项目:国家自然科学基金项目(81071650)；辽宁省科技厅科学技术计划项目 (2013225585)；辽宁省高等学校攀登学者计划（2009） |
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| 中文摘要: |
| 摘 要：环状RNA（circRNA）是一类不同于线性RNAs，可形成共价闭锁环结构，在哺乳动物体内具有巨大基因调控功能的非编码RNAs，其主要来源于外显子或内含子，经索尾插接或套索内含子方式产生，具有数量巨大，进化保守、在细胞质中稳定性高等特点，具有microRNA分子海绵、结合RNA相关蛋白形成RNA-蛋白质复合物和基因转录调控等作用。CircRNA可与肿瘤相关的miRNA形成circRNA-miRNA轴参与肿瘤相关信号通路的调控。全文从circRNA的种类、成环机制、功能及其在肿瘤中的作用及最新进展等方面作一综述。 |
| 英文摘要: |
| Abstract：Circular RNAs(circRNAs) are a large class of RNAs which can form covalently closed continuous loops and act as gene regulators in mammals. The circRNAs are mainly generated from exons and introns by back splicing or lariat introns. They are enormously abundant，evolutionally conserved and relatively stable in cytoplasm. CircRNAs can function as microRNA sponges，binding to RNA-associated proteins to form RNA-proteins complexes and modifiers of genetic transcription. Importantly，circRNAs interact with cancer-related miRNAs and the circRNA-miRNA axes play a vital role in cancer-related pathways. This article aims to review the latest research progress on the classification，mechanism of cyclization，functions of circRNAs and its roles in cancer. |
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