| 温月凤,曾丽斯,黄文瑾.循环肿瘤细胞与Ⅰ~ⅡA期宫颈癌临床病理参数的相关性[J].肿瘤学杂志,2018,24(3):247-249. |
| 循环肿瘤细胞与Ⅰ~ⅡA期宫颈癌临床病理参数的相关性 |
| Correlation of Circulating Tumor Cells with Clinicopathological Parameters in Patients with Stage Ⅰ~ⅡA Cervical Carcinoma |
| 投稿时间：2017-06-30 |
| DOI：10.11735/j.issn.1671-170X.2018.03.B014 |
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| 中文关键词: 循环肿瘤细胞 宫颈癌 临床病理参数 |
| 英文关键词:circulating tumor cells cervical carcinoma clinicopathological parameters |
| 基金项目:广州市医学重点学科建设项目（2017-2019年） |
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| 中文摘要: |
| 摘 要：［目的］ 分析Ⅰ~Ⅱ宫颈癌患者外周血循环肿瘤细胞的表达与其临床病理参数相关性。［方法］ 以莱尔生物循环肿瘤细胞检测技术检测69例初治Ⅰ~ⅡA期宫颈癌和20例正常人中循环肿瘤细胞的表达情况，并与Ⅰ~ⅡA期宫颈癌临床病理参数做相关分析。［结果］ Ⅰ~ⅡA期宫颈癌和正常人中循环肿瘤细胞阳性率分别为47.8％和0(P<0.05)。在SCC≤1.5ng/ml和SCC>1.5ng/ml组中，循环肿瘤细胞阳性率分别为33.3％和59.0%(P=0.035)；在无盆腔淋巴结转移和有盆腔淋巴结转移组中，循环肿瘤细胞阳性率分别为39.2%和72.2％(P=0.035)；在无淋巴血管间隙受侵和有淋巴血管间隙受侵组中，循环肿瘤细胞阳性率分别为41.8%和71.4％(P=0.048)。在不同的年龄、病理类型和分期以及是否有宫旁浸润和深肌层浸润的各组中，循环肿瘤细胞表达差异均无统计学意义(P>0.05)。［结论］ 循环肿瘤细胞与Ⅰ~ⅡA期宫颈癌盆腔淋巴结转移、淋巴血管间隙受侵和SCC密切相关，可用于评估Ⅰ~ⅡA期宫颈癌的病情。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate correlation of circulating tumor cells(CTCs) expression with clinicopathological parameters in stage Ⅰ~ⅡA cervical carcinoma patients，and explore its clinical significance. ［Methods］ A total of 69 stage Ⅰ~ⅡA cervical carcinoma patients and 20 healthy people were evaluated by CyttelBio CTC detection technology for detecting CTCs，and the correlation of CTCs with patients’ clinicopathological parameters was also analyzed．［Results］ The positive rate of CTCs in patients with stage Ⅰ~ⅡA cervical carcinoma and the healthy people was 47.8％ and 0，respectively，and the difference was statistically significant(P<0.05). In patients with SCC≤1.5ng/ml and SCC>1.5ng/ml，the positive rate of CTCs were 33.3％ and 59.0%，respectively(P=0.035). The positive rate of CTCs in patients with negative and positive pelviclymph node metastasis were 39.2% and 72.2％，respectively(P=0.035)，the positive rate of CTCs in patients with negative and positive lymphovascular involvement were 41.8% and 71.4％，respectively(P=0.048). In patients with different age，histological type，stage，parametrialextension or deepstromalinvation，CTCs expression had no significant difference(P>0.05). ［Conclusion］ CTCs are closely related with stage Ⅰ~ⅡA cervical carcinoma’s pelviclymph node metastasis，lymphovascular involvement and SCC level，and can be used to evaluate stage Ⅰ~ⅡA cervical carcinoma. |
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