| 李 杨,陈贡斌,闫艳菊.奈达铂+替吉奥化疗方案联合3D-CRT治疗局部晚期食管癌临床研究[J].肿瘤学杂志,2018,24(2):125-128. |
| 奈达铂+替吉奥化疗方案联合3D-CRT治疗局部晚期食管癌临床研究 |
| Clinical Study of Nedaplatin+S1 Regimen Combined with 3D-CRT for Patients with Locally Advanced Esophageal Cancer |
| 投稿时间：2016-12-20 |
| DOI：10.11735/j.issn.1671-170X.2018.02.B009 |
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| 中文关键词: 铂类 S-1 局部晚期食管肿瘤 疗效 安全性 |
| 英文关键词:platinum S-1 locally advanced esophageal cancer clinical efficacy safety |
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| 中文摘要: |
| 摘 要：［目的］ 探讨奈达铂+替吉奥化疗方案联合3D-CRT对局部晚期食管癌患者近期疗效、生存时间及不良反应的影响。［方法］ 2012年8月至2014年8月收治的局部晚期食管癌患者130例，随机数字表法分为对照组（65例）和观察组（65例），对照组在3D-CRT基础上给予奈达铂单用，观察组在对照组基础上加用替吉奥（S-1）辅助治疗；比较两组患者临床疗效，中位无进展生存时间，中位总生存时间，Karnofsky评分改善情况及不良反应发生率。［结果］ 观察组患者临床疗效显著优于对照组（P<0.05）；观察组患者中位无进展生存时间和中位总生存时间均显著长于对照组（P<0.05）；观察组患者Karnofsky评分改善情况显著优于对照组（P<0.05）；观察组患者1～2度白细胞减少和厌食发生率均显著高于对照组（P<0.05）；两组患者血小板减少、血红蛋白减少、恶心呕吐及放射性食管炎发生率比较差异无显著性（P>0.05）。［结论］ 奈达铂+替吉奥化疗方案联合3D-CRT治疗局部晚期食管癌可提高疗效，延长生存时间，提高生活质量，且未导致严重不良反应发生。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the role of Nedaplatin+S1 regimen combined with 3D-CRT in short-term，survival time and toxicity of patients with locally advanced esophageal cancer.［Methods］ One hundred and thirty cases with locally advanced esophageal cancer were chosen in the period from August 2012 to August 2014 and randomly divided into two groups including control group(65 patients) with nedaplatin used alone and observation group(65 patients) with nedaplatin combined with S-1 on the basis of 3D-CRT. The clinical efficacy，the median progression free survival time，the median overall survival time，the improving effects of Karnofsky score and the toxicity rate of both groups were compared.［Results］ The clinical efficacy of observation group were significant better than that in control group（P<0.05）. The median progression free survival time and the median overall survival time of observation group were significant longer than those in control group（P<0.05）.The improving effects of Karnofsky score of observation group were significant better than that in control group（P<0.05）. The incidences of 1～2 grade neutropenia and anorexia of observation group were significant higher than those in control group（P<0.05）. There was no significant difference in the incidence of thrombocytopenia reduction，hemoglobin reduction，nausea and vomiting，and radiation esophagitis between the 2 groups(P>0.05）.［Conclusion］ Nedaplatin+S1 regimen combined with 3D-CRT in the treatment of patients with locally advanced esophageal cancer can efficiently delay the disease progression，prolong the survival time，improve the quality life and not cause serious adverse reactions. |
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