| 贾艳云,苏冬菊,邵 路.LncRNA HOTAIR与肺癌相关性的研究进展[J].肿瘤学杂志,2018,24(1):1-5. |
| LncRNA HOTAIR与肺癌相关性的研究进展 |
| Research Progress on Correlation Between LncRNA HOTAIR and Lung Cancer |
| 投稿时间：2017-05-31 |
| DOI：10.11735/j.issn.1671-170X.2018.01.B001 |
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| 中文关键词: lncRNA 肺癌 HOTAIR 侵袭 转移 |
| 英文关键词:lncRNA lung cancer HOTAIR invasion metastasis |
| 基金项目:黑龙江省青年科学基因项目（QC2011C047）；黑龙江省教育厅科学技术研究项目（12511z014） |
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| 中文摘要: |
| 摘 要：长链非编码RNA（lncRNAs）控制着几乎所有的生物过程，lncRNA HOX转录反义RNA (HOTAIR)通过其相关蛋白来抑制基因表达。HOTAIR增加肺癌细胞的增殖、侵袭、转移及耐药能力，其在肺癌中的高表达与肺癌的转移及不良预后相关。全文回顾长链非编码RNA HOTAIR介导的肺癌侵袭性表现的分子机制，并且讨论了HOTAIR在肺癌诊断和治疗方面的潜力。 |
| 英文摘要: |
| Abstract：Long non-coding RNAs(lncRNAs) dominate almost all biological processes. lncRNA HOX transcript antisense RNA(HOTAIR) represses gene expression through its protein partners. HOTAIR promotes proliferation，invasion，metastasis，and drug resistance of lung cancer cells ，and the expression of HOTAIR is elevated in lung cancer and associates with metastasis and poor prognosis. Here we review the molecular mechanisms underlying HOTAIR-mediated aggressive phenotypes of lung cancer，and the potential application of HOTAIR in diagnosis and treatment of lung cancer is also discussed. |
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