赵 冲,汪 强,武奋萍.CDCA7L在结肠癌患者组织标本中的表达及临床意义[J].肿瘤学杂志,2017,23(10):885-889. |
CDCA7L在结肠癌患者组织标本中的表达及临床意义 |
Expression and Clinical Significance of CDCA7L in Patients with Colon Cancer |
投稿时间:2017-02-19 |
DOI:10.11735/j.issn.1671-170X.2017.10.B010 |
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中文关键词: CDCA7L 结肠癌 预后 |
英文关键词:CDCA7L colon cancer prognosis |
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中文摘要: |
摘 要:[目的] 探讨CDCA7L在结肠癌组织中表达及临床意义。[方法] 通过QRT-PCR及免疫组织化学法检测CDCA7L mRNA及蛋白在65例结肠癌组织及癌旁组织标本中的表达,分析其表达与患者临床病理特征及预后的关系。[结果] CDCA7L在结肠癌组织标本中的表达较癌旁组织明显增高(81.54% vs 6.15%,P<0.001)。CDCA7L的表达与患者性别、年龄及肿瘤部位无关 (P均>0.05 ),与分期、淋巴结转移、远处转移、肿瘤分化、血清CEA水平及生存状态明显相关(P均<0.05)。高表达CDCA7L患者的总生存时间及中位生存时间均较低表达者明显缩短(27.00±3.32个月 vs 43.72±3.08个月,13.00±1.49个月 vs 27.01±1.87个月;P<0.001)。Cox多因素回归模型分析提示,CDCA7L表达、远处转移及临床分期是结肠癌独立的预后因素(P<0.05)。[结论] CDCA7L参与调节结肠癌的发生发展,可作为潜在的结肠癌诊断和预后评估的分子标志物。 |
英文摘要: |
Abstract:[Objective] To investigate the expression and clinical significance of CDCA7L in colon carcinoma.[Methods] The expression of CDCA7L mRNA and protein were detected by QRT-PCR and immunohistochemistry in 65 cases of colon cancer tissues and adjacent tissues,and the relationship of CDCA7L expression with the clinicopathological features and prognosis of the patients were analyzed. [Results] The expression of CDCA7L in colon cancer tissue specimens was higher than that in noncancerous tissue(81.54% vs 6.15%,P<0.001).CDCA7L expression was not related to gender,age and tumor location(all P>0.05),but was related to stage,lymph node metastasis,distant metastasis,differentiation,serum CEA levels and survival status (all P<0.05).Furthermore,overall survival time and median survival time of patients with high expression of CDCA7L was shorter (27.00±3.32m vs 43.72±3.08m,13.00±1.49m vs 27.01±1.87m,P<0.001).Cox multivariate regression model analysis showed that CDCA7L expression,distant metastasis and clinical stage were the independent prognostic factors(P<0.05). [Conclusion] CDCA7L is involved in the regulation of colon cancer,and can be used as a molecular marker for the diagnosis and prognosis of colon cancer. |
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