| 赵 冲,汪 强,武奋萍.CDCA7L在结肠癌患者组织标本中的表达及临床意义[J].肿瘤学杂志,2017,23(10):885-889. |
| CDCA7L在结肠癌患者组织标本中的表达及临床意义 |
| Expression and Clinical Significance of CDCA7L in Patients with Colon Cancer |
| 投稿时间：2017-02-19 |
| DOI：10.11735/j.issn.1671-170X.2017.10.B010 |
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| 中文关键词: CDCA7L 结肠癌 预后 |
| 英文关键词:CDCA7L colon cancer prognosis |
| 基金项目: |
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| 摘要点击次数: 2091 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨CDCA7L在结肠癌组织中表达及临床意义。［方法］ 通过QRT-PCR及免疫组织化学法检测CDCA7L mRNA及蛋白在65例结肠癌组织及癌旁组织标本中的表达，分析其表达与患者临床病理特征及预后的关系。［结果］ CDCA7L在结肠癌组织标本中的表达较癌旁组织明显增高(81.54% vs 6.15%，P<0.001)。CDCA7L的表达与患者性别、年龄及肿瘤部位无关 (P均>0.05 )，与分期、淋巴结转移、远处转移、肿瘤分化、血清CEA水平及生存状态明显相关(P均<0.05)。高表达CDCA7L患者的总生存时间及中位生存时间均较低表达者明显缩短（27.00±3.32个月 vs 43.72±3.08个月，13.00±1.49个月 vs 27.01±1.87个月；P<0.001）。Cox多因素回归模型分析提示，CDCA7L表达、远处转移及临床分期是结肠癌独立的预后因素(P<0.05)。［结论］ CDCA7L参与调节结肠癌的发生发展，可作为潜在的结肠癌诊断和预后评估的分子标志物。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression and clinical significance of CDCA7L in colon carcinoma.［Methods］ The expression of CDCA7L mRNA and protein were detected by QRT-PCR and immunohistochemistry in 65 cases of colon cancer tissues and adjacent tissues，and the relationship of CDCA7L expression with the clinicopathological features and prognosis of the patients were analyzed. ［Results］ The expression of CDCA7L in colon cancer tissue specimens was higher than that in noncancerous tissue(81.54% vs 6.15%，P<0.001).CDCA7L expression was not related to gender，age and tumor location(all P>0.05)，but was related to stage，lymph node metastasis，distant metastasis，differentiation，serum CEA levels and survival status (all P<0.05).Furthermore，overall survival time and median survival time of patients with high expression of CDCA7L was shorter (27.00±3.32m vs 43.72±3.08m，13.00±1.49m vs 27.01±1.87m，P<0.001).Cox multivariate regression model analysis showed that CDCA7L expression，distant metastasis and clinical stage were the independent prognostic factors(P<0.05). ［Conclusion］ CDCA7L is involved in the regulation of colon cancer，and can be used as a molecular marker for the diagnosis and prognosis of colon cancer. |
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