| 许春本,徐子海,朱超华.原发性肝癌伽玛刀立体定向放疗的疗效分析[J].肿瘤学杂志,2017,23(10):872-876. |
| 原发性肝癌伽玛刀立体定向放疗的疗效分析 |
| Efficacy of Gamma-knife Stereotactic Body Radiotherapy for Primary Liver Cancer |
| 投稿时间：2017-01-19 |
| DOI：10.11735/j.issn.1671-170X.2017.10.B008 |
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| 中文关键词: 肝肿瘤 放射疗法 伽玛刀 SBRT 预后 |
| 英文关键词:liver neoplasms radiotherapy Gamma-knife SBRT prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 分析伽玛刀立体定向放射治疗原发性肝癌的疗效及预后因素。［方法］ 对66例原发性肝癌患者行伽玛刀治疗，以50%～70%的等剂量曲线覆盖95%的计划靶区，处方剂量3.8～6.0Gy/次，照射次数6～10次，肿瘤剂量30～60Gy，照射3次/周，隔日1次，总疗程2～3周。［结果］ 近期疗效总有效率（CR+PR）为80.3%(53/66)，1、2、3年生存率分别为48.5%、24.2%、18.2%。Cox多因素分析显示肿瘤分期和肿瘤最大径是独立预后影响因素。［结论］ 伽玛刀治疗能有效改善原发性肝癌的肿瘤局部控制率和预后。 |
| 英文摘要: |
| Abstract：［Objective］ To analyze the efficacy of Gamma-knife stereotactic body radiotherapy in treatment of patients with primary liver cancer(PLC). ［Methods］ Sixty-six patients with primary liver cancer underwent Gamma-knife radiotherapy. During the procedure the 50%～70% isodose line covered 95% of planning target volume. The radiotherapy regimen consisted of 30～60Gy in 6～10 fraction with 3.8～6.0Gy per fraction，the treatment was delivered 3 times per week during every other day. ［Results］ The response rate(CR+PR) was 80.3%(53/66)，the overall 1-，2- and 3-year survival was 48.5%，24.2% and 18.2%，respectively. Multivariate Cox analysis showed that BCLC stage and tumor size were independent prognostic factors for patients. ［Conclusion］ Gamma knife radiotherapy for the treatment of primary liver cancer can effectively improve the local control rate and prognosis of patients. |
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