| 许来艳.1H-MRS在预测胶质瘤浸润范围及判断肿瘤级别中的临床应用价值[J].肿瘤学杂志,2017,23(10):854-857. |
| 1H-MRS在预测胶质瘤浸润范围及判断肿瘤级别中的临床应用价值 |
| Clinical Value of 1H-MRS in Predicting the Infiltrative Range and Evaluating Tumor Grade of Gliomas |
| 投稿时间：2016-12-30 |
| DOI：10.11735/j.issn.1671-170X.2017.10.B004 |
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| 中文关键词: 1H-MRS 胶质瘤 肿瘤级别 浸润 |
| 英文关键词:1H-MRS glioma tumor grade invasion |
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| 中文摘要: |
| 摘 要：［目的］探讨1H-MRS在预测各级别胶质瘤浸润范围及判断肿瘤级别的临床应用价值。［方法］ 选取行术前MR检查以及1H-MRS检查的脑胶质瘤患者62例，另设20例正常成人为对照组。比较不同级别患者肿瘤组织、肿瘤周围组织、不同周围水肿组间的Cho/Cr、NAA/ Cho、NAA/Cr比值。［结果］ 高级别、低级别组肿瘤组织及对照组3组间NAA/Cr、Cho/Cr和NAA/Cho比值差异有统计学意义（P<0.05）。不同组间瘤周组织NAA/Cr、Cho/Cr和NAA/Cho比值差异有统计学意义（P<0.05）。肿瘤周围有水肿组的肿瘤组织、瘤周组织与对照组间的NAA/Cr、Cho/Cr和NAA/Cho比值差异均有统计学意义（P<0.05）。［结论］ 1H-MRS能在分子水平上反映肿瘤的胆碱、脂质等化合物代谢的异常变化，可为胶质瘤级别及肿瘤浸润范围判断提供参考依据。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the clinical value of 1H-MRS in predicting the infiltrative range and evaluating tumor grade of gliomas. ［Methods］ Six-two patients with gliomas received MR examination and 1H-MRS examination were selected. Another 20 healthy adults were selected as control group. The Cho/Cr，NAA/Cho，and NAA/Cr values of the tumor tissue and surrounding tissue of patients in different levels and different surrounding edema were compared. ［Results］ There were significant differences in NAA/Cr，Cho/Cr，and NAA/Cho ratios between the high-level，low-level tumor tissues and the control group(P<0.05).There were significant differences in NAA/Cr，Cho/Cr，and NAA/Cho ratios among tumor surrounding tissues of different groups(P<0.05).There were significant differences in NAA/Cr，Cho/Cr，and NAA/Cho ratios between tumor surrounding edema，surrounding tissue and control group(P<0.05). ［Conclusion］ 1H-MRS can reflect the abnormal changes of chemical compound metabolism such as luridine and lipid of tumor in molecule level，to indicate the tumor cell multiplication and neuron injury and provide reference to the evaluation of glioma grade and tumor invasion. |
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