| 郭利伟,陈爱萍,王 华.尿液外泌体在泌尿系统肿瘤中的研究进展[J].肿瘤学杂志,2017,23(7):593-597. |
| 尿液外泌体在泌尿系统肿瘤中的研究进展 |
| New Progress on Urinary Exosome in Urological Cancer |
| 投稿时间：2017-03-02 |
| DOI：10.11735/j.issn.1671-170X.2017.07.B006 |
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| 中文关键词: 泌尿系统肿瘤 尿液 外泌体 靶向治疗 |
| 英文关键词:urological cancer urine exosome targeted therapy |
| 基金项目:国家自然科学基金(81402117)；浙江省自然科学基金（LY17H160043）；浙江省钱江人才计划（QJD1602025）；浙江省卫生科技计划（2015111814） |
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| 中文摘要: |
| 摘 要：外泌体是细胞主动分泌的具有脂质双分子层的小囊泡。尿液是在泌尿系统中产生，并存在大量的外泌体。肿瘤在发生、发展过程中能不断释放外泌体到细胞外。通过检测尿液中的外泌体可能早期追踪及监控泌尿系统肿瘤，代替活检穿刺或影像学等检测。外泌体还可用于脂溶性药物的装载、靶向药物及免疫疫苗的制备。全文对尿液外泌体的提取及其在泌尿系统肿瘤诊断、治疗的应用进展进行综述。 |
| 英文摘要: |
| Abstract：Exosomes are defined as nanovesicles，which compriseing a lipid bilayer membrane，that can be secreted by tumor cells. The urine produced by the urology system，which contains a large number of exosome. The exosome can be secreted by tumor cell during the tumor progression and development. Urinary exosomes can be used for the diagnosis and monitoring of urological tumors. The urinary exosomes also have potential as targeted-drug carriers and tumor vaccine. This article reviews the recent advances in the extraction of urinary exosomes and their application in the diagnosis and treatment of urinary system tumors. |
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