| 万晓晨,马小红,程 璐.FAM3C蛋白与结肠癌临床病理相关性[J].肿瘤学杂志,2017,23(5):413-416. |
| FAM3C蛋白与结肠癌临床病理相关性 |
| Correlation Between FAM3C Expression and Clinicopathological Features of Colon Cancer |
| 投稿时间：2017-02-03 |
| DOI：10.11735/j.issn.1671-170X.2017.05.B011 |
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| 中文关键词: FAM3C蛋白 结肠癌 转移 预后 |
| 英文关键词:FAM3C colon cancer metastasis prognosis |
| 基金项目:浙江省医药卫生一般研究计划（2014KYA003， 2012KYA005， 2012KYA008） |
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| 中文摘要: |
| 摘 要：［目的］ 研究FAM3C在结肠癌中的表达及其与结肠癌临床病理的相关性。［方法］ 用免疫组织化学法检测结肠癌组织芯片FAM3C的蛋白表达，分析其与临床病理相关性，Kaplan-Meier生存分析及Cox回归模型分析其预后。［结果］ FAM3C蛋白在结肠癌中表达水平与肿瘤TNM分期及淋巴结转移具有显著性相关；Kaplan-Meier生存分析显示FAM3C蛋白表达阳性组生存率显著低于阴性组，Cox回归模型行多因素分析显示FAM3C蛋白不是结肠癌独立预后的因子。［结论］ FAM3C高表达可能参与了结肠癌转移过程，甚至促使结肠癌的恶性进展；其高表达可能与结肠癌患者的生存及预后不良具有相关性。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the correlation between FAM3C expression and clinicopathological features of colon cancer. ［Methods］ The protein level of FAM3C was detected by immunohistochemical staining and the relationship between the expression of FAM3C and clinicopathological features was analyzed. Kaplan-Meier survival analysis and Cox regression model were used to analyze the relationship between FAM3C and prognosis. ［Results］ FAM3C protein level was significantly correlated with TNM stage and lymph node metastasis in colon cancer. Kaplan-Meier survival analysis showed that the survival of patients with positive expression of FAM3C was significantly lower than those with negative expression，Cox regression model analysis showed that the FAM3C protein level was not an independent prognostic factor for colon cancer. ［Conclusion］ High expression of FAM3C may be involved in the metastasis of colon cancer，and even promote the malignant progression of colon cancer. Thus，high expression of FAM3C may be related to the survival and prognosis of patients with colon cancer. |
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