| 艾尼·沙塔尔,吐尔逊太·木哈买提,苏 毅.三阴性乳腺癌中MAPK及SNAIL蛋白的表达及临床意义[J].肿瘤学杂志,2017,23(5):405-408. |
| 三阴性乳腺癌中MAPK及SNAIL蛋白的表达及临床意义 |
| Expression of MAPK and SNAIL Protein in Triple Negative Breast Cancer and its Clinical Significance |
| 投稿时间：2016-12-08 |
| DOI：10.11735/j.issn.1671-170X.2017.05.B009 |
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| 中文关键词: 三阴性乳腺癌 丝裂原活化蛋白激酶 Snail 蛋白 复发 转移 |
| 英文关键词:triple negative breast cancer mitogen activated protein kinase Snail recurrence metastasis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨三阴性乳腺癌组织中丝裂原活化蛋白激酶（MAPK）及Snail 蛋白的表达及其临床意义。［方法］ 选取2009年1月至2011年2月三阴性乳腺癌患者石蜡组织标本50例及20例癌旁正常乳腺石蜡组织为研究对象，应用免疫组化SP法检测MAPK及Snail 蛋白在三阴性乳腺癌组织中和癌旁正常乳腺组织中的表达水平，并分析其与三阴性乳腺癌复发转移及临床病理参数的关系。［结果］ MAPK及Snail蛋白在三阴性乳腺癌组织中的阳性表达水平显著性高于癌旁正常乳腺组织（P<0.05）；MAPK阳性表达与三阴性乳腺癌患者的年龄、肿瘤家族史、病理类型、组织学分级、腋淋巴结转移、临床病理分期均无显著性相关性（P>0.05），Snail蛋白阳性表达与三阴性乳腺癌患者的腋淋巴结转移、临床病理分期具有相关（P<0.05）。至随访截止时间，50例患者发生复发转移24例，其中MAPK及Snail蛋白在三阴性乳腺癌复发转移患者中的阳性表达水平显著性高于未复发转移患者（P<0.05）。［结论］ MAPK及Snail蛋白可能参与了三阴性乳腺癌的发展，并有可能成为判断三阴性乳腺癌复发转移的生物学指标。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of mitogen-activated protein kinase(MAPK) and Snail protein in triple negative breast cancer tissues and its clinical significance. ［Methods］ Fifty triple negative breast cancer tissues and 20 adjacent normal breast tissue were selected from our hospital from January 2009 to February 2016，the expression of MAPK and Snail protein immunohistochemical SP method were used to analyze the relationship between expression of MAPK and Snail protein and clinicopathological parameters of triple negative breast cancer. ［Results］ The expression of MAPK and Snail protein in triple negative breast cancer tissues was significantly higher than that in adjacent normal breast tissues(P<0.05). MAPK positive expression of triple negative breast cancer wasn’t correlated with age，family history of cancer，histological type，histological grade，axillary lymph node metastasis，clinical stage(P>0.05). The positive expression of Snail protein was correlated with axillary lymph node metastasis and clinical staging (P<0.05). Followed-up to the deadline，24 cases of 50 patients occurred recurrence，the positive expression of MAPK and Snail protein in patients with recurrence and metastasis was significantly higher than that without recurrence and metastasis(P<0.05). ［Conclusion ］ MAPK and Snail protein may be involved in the development of triple negative breast cancer，and used as a biological marker for predicting recurrence and metastasis. |
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