| 刘 钢.凋亡抑制基因BAG-1在甲状腺癌中的表达及临床意义[J].肿瘤学杂志,2017,23(4):268-272. |
| 凋亡抑制基因BAG-1在甲状腺癌中的表达及临床意义 |
| Expression of Apoptosis Suppression Gene BAG-1 and its Clinical Significance in Thyroid Carcinoma |
| 投稿时间：2016-12-20 |
| DOI：10.11735/j.issn.1671-170X.2017.04.B003 |
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| 中文关键词: 甲状腺肿瘤 BAG-1基因 免疫组织化学 |
| 英文关键词:thyroid neoplasms BAG-1 gene immunohistochemistry |
| 基金项目:湖北省黄石市医学卫生科研立项（科技攻关项目）（黄科技农发［2006］1号） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨凋亡抑制基因BAG-1在甲状腺癌中的表达及其临床意义。［方法］ 应用免疫组化SP法检测78例甲状腺癌、62例甲状腺腺瘤、37例癌旁组织和28例正常甲状腺组织中BAG-1的表达情况，并比较其表达差异，分析 BAG-1的表达与甲状腺癌临床病理特征的关系。［结果］ 甲状腺癌、甲状腺瘤、癌旁甲状腺及正常甲状腺组织中BAG-1的阳性表达率分别为74.36%，40.32%，16.22%和0。未分化型甲状腺癌（未分化癌和髓样癌）组织中的BAG-1阳性率较分化型甲状腺癌增高（100.0% vs 69.23%，P<0.05）；有淋巴结转移和临床Ⅲ、Ⅳ期病例组的BAG-1阳性率较无淋巴结转移组、临床Ⅰ、Ⅱ期病例增高（92.9% vs 64.0%，95.8% vs 64.8%，P均<0.05）。［结论］ BAG-1在甲状腺癌中高表达，其过量表达可能与肿瘤的发生发展有关。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of apoptosis suppression gene BAG-1 in thyroid carcinoma and its clinical significance. ［Methods］ The expression of BAG-1 was analyzed by immunohistochemical SP method in 72 samples of thyroid carcinoma，58 samples of thyroid thyroid adenoma，34 samples of cancer adjacent thyroid tissue and 26 samples of normal thyroid tissue. The positive expression rates of BAG-1 in different thyroid tissues were compared. And the relationship of BAG-1 expression with clinicopathological features of thyroid carcinoma was analyzed.［Results］ The positive rates of BAG-1 of throid carcinoma，thyroid adenoma，cancer adjacent thyroid tissues and normal thyroid tissues were 74.36%，40.32%，16.22% and 0 (compared to norml tyroid tissue P<0.05 or P<0.01)，respectively. The positive rates of BAG-1 in the non-differentiated thyroid carcinoma（undifferentiated carcinoma and medullary carcinoma）were significantly higher than that in the differentiated thyroid carcinoma（100.0% vs 69.23%，P<0.05）. The positive rates of BAG-1 in thyroid cancer with positive lymph node metastases or stage Ⅲ，Ⅳ carcinoma were significantly higher than that in tyroid cancer with negative lymph node metastases or stage Ⅰ，Ⅱ carcinoma（92.9% vs 64.0%，95.8% vs 64.8%，all P<0.05）. ［Conclusion］ The BAG-1 is overexpressed in thyroid carcinoma，it may be related to the carcinogenesis and development of thyroid carcinoma． |
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