| 展鹏远,王晓磊,郭 伟.胆囊癌中B7-H1和B7-H4的表达及临床意义[J].肿瘤学杂志,2017,23(2):130-133. |
| 胆囊癌中B7-H1和B7-H4的表达及临床意义 |
| Expression of B7-H1 and B7-H4 in Gallbladder Cancer and Their Significance |
| 投稿时间：2016-06-12 |
| DOI：10.11735/j.issn.1671-170X.2017.02.B011 |
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| 中文关键词: 胆囊肿瘤 B7-H1 B7-H4 免疫组织化学 |
| 英文关键词:gallbladder neoplasms B7-H1 B7-H4 immunohistochemistry |
| 基金项目:开封市科技发展计划项目(130351) |
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| 摘要点击次数: 1782 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨胆囊癌中B7-H1和B7-H4的表达及其临床意义。［方法］ 应用免疫组织化学SP法检测60例胆囊癌组织中B7-H1、B7-H4的表达，分析两者与胆囊癌临床病理特征的关系。［结果］ B7-H1和B7-H4在胆囊癌中的阳性表达率显著高于癌旁组织 (46.7% vs 5.0%，55.0% vs 0)（P均<0.05）。B7-H1、B7-H4在Nevin(Ⅳ+Ⅴ)期、淋巴结转移组中的阳性表达率显著高于Nevin（Ⅰ+Ⅱ+Ⅲ）期、无淋巴结转移组(P＜0.05)，B7-H1、B7-H4与性别、年龄、合并胆囊结石、肿瘤组织学类型及分化程度无相关性(P>0.05)。B7-H1、B7-H4在胆囊癌中表达呈正相关（r=0.30，P<0.05）。［结论］ B7-H1和B7-H4可能在胆囊癌的发生发展中起一定的作用。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the significance of B7-H1 and B7-H4 expression in gallbladder cancer. ［Methods］ The expressions of B7-H1 and B7-H4 were detected by immunohistochemistry (SP) method in 60 specimens of gallbladder cancer tissues and 20 specimens of tumor-adjacent tissues，and their correlation with the clinicopathologic characteristics of gallbladder cancer were analyzed. ［Results］ The expressions of B7-H1 and B7-H4 were significant higher in gallbladder cancer tissue than those in tumor-adjacent tissue(46.7% vs 5.0%，55.0% vs 0.0%；P<0.05). The expressions of B7-H1 and B7-H4 in gallbladder cancer were positively correlated with each other. The expressions of B7-H1 and B7-H4 were significantly higher in Nevin stage(Ⅳ+Ⅴ) group and lymph node metastasis group than those in Nevin stage(Ⅰ+Ⅱ+Ⅲ) group and lymph node metastasis-free group，respectively(P<0.05)，but they had no correlations with age，sex，complicated cholelithiasis，histological types or tumor differentiation(P>0.05). ［Conclusion］ B7-H1 and B7-H4 may play a role in the occurrence and development of gallbladder cancer. It might provide new means of immunotherapy and gene therapy for gallbladder cancer. |
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