罗何三,吴盛喜,许鸿鹞.术前放疗加手术与单纯手术治疗喉癌生存率比较的Meta分析[J].肿瘤学杂志,2016,22(11):934-941. |
术前放疗加手术与单纯手术治疗喉癌生存率比较的Meta分析 |
Survival Rate of Laryngeal Carcinoma Patients Receiving Preoperative Radiation and Surgery Versus Surgery Alone: A Meta Analysis |
投稿时间:2016-05-31 |
DOI:10.11735/j.issn.1671-170X.2016.11.B013 |
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中文关键词: 喉肿瘤 放射疗法 手术 Meta分析 |
英文关键词:laryngeal neoplasms radiation therapy surgery Meta analysis |
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中文摘要: |
摘 要:[目的] 比较术前放疗加手术与单纯手术治疗喉癌的疗效,为喉癌治疗方式的选择提供可靠的循证依据。[方法] 检索国内外有关数据库查找符合检索条件的前瞻性临床随机对照试验,采用Meta分析的方法,对国内外公开发表的有关术前放疗加手术与单纯手术治疗喉癌的临床随机对照试验的研究文献进行综合分析。[结果] 共纳入5个随机对照试验,研究对象共1086例。术前放疗加手术与单纯手术相比并未提高喉癌患者的3和5年生存率,RR 分别为0.94(95%CI为0.71~1.24)和1.09(95%CI为0.88~1.34)。术前放疗加手术与单纯手术相比治疗声门上型、声门型以及Ⅱ、Ⅲ、Ⅳ期喉癌3年生存率,差异均无统计学意义,RR 分别为0.93(95%CI为0.61~1.42,P=0.73)、0.55(95%CI为0.26~1.19,P=0.13)、0.86(95%CI为0.34~2.15,P=0.74)、0.82(95%CI为0.46~1.47,P=0.50)和0.74(95%CI为0.44~1.25,P=0.26)。术前放疗加手术与单纯手术相比治疗声门上型、声门型以及Ⅰ/Ⅱ和Ⅲ/Ⅳ期喉癌5年生存率,差异均无统计学意义,RR 分别为1.01(95%CI为0.80~1.28,P=0.92)、1.06(95%CI为0.67~1.67,P=0.80)、0.97(95%CI为0.86~1.09,P=0.63)和1.01(95%CI为0.90~1.13,P=0.91)。[结论] 本系统评价纳入研究有限,结果提示术前放疗加手术治疗对比手术治疗并未提高喉癌患者的生存率,需进一步开展更多高质量临床研究进行验证。 |
英文摘要: |
Abstract:[Objective] To compare the efficacy of preoperative radiation and surgery with surgery alone in treatment of patients with laryngeal cancer.[Methods] The electronic databases were searched to find the prospective randomized controlled clinical trials preoperative radiation and surgery or surgery alone for laryngeal cancer.[Results] Five randomized controlled trails involving 1086 patients were included.There was no difference between the two treatments in terms of three-year and five-year survival,and RR were 0.94(95%CI:0.71~1.24) and 1.09(95%CI:0.88~1.34),respectively.There was no difference between the two treatments in terms of three-year survival for supraglottic carcinoma,glottic carcinoma and laryngeal carcinoma (stage Ⅱ,Ⅲ and Ⅳ),and RR were 0.93(95%CI:0.61~1.42,P=0.73),0.55(95%CI:0.26~1.19,P=0.13),0.86(95%CI:0.34~2.15,P=0.74),0.82(95%CI:0.46~1.47,P=0.50) and 0.74(95%CI:0.44~1.25,P=0.26),respectively. There was no difference between the two treatments in terms of five-year survival for supraglottic carcinoma,glottic carcinoma and laryngeal carcinoma(stage Ⅰ/Ⅱ and Ⅲ/Ⅳ),and RR were 1.01(95%CI:0.80~1.28,P=0.92),1.06(95%CI:0.67~1.67,P=0.80),0.97(95%CI:0.86~1.09,P=0.63)and 1.01(95%CI:0.90~1.13,P=0.91),respectively. [Conclusion] The study indicates that preoperative radiation and surgery does not improve five-year survival for laryngeal cancer compared with surgery alone. |
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