丁 矢,郭玉凤,杜 维.GSK3β和CyclinD1在胃癌组织中的表达及临床意义[J].肿瘤学杂志,2015,21(7):577-580. |
GSK3β和CyclinD1在胃癌组织中的表达及临床意义 |
Expressions of Glycogen Synthase Kinase 3 Beta and CyclinD1 in Gastric Cancer and Their Clinical Significance |
投稿时间:2014-05-10 |
DOI:10.11735/j.issn.1671-170X.2015.07.B010 |
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中文关键词: 胃肿瘤 GSK3β CyclinD1 组织微阵列 免疫组织化学 |
英文关键词:gastric neoplasms GSK3β,CyclinD1 microtissue array immunohistochemistry |
基金项目:湖南医药卫生科技计划项目(B2013148);湖南省教育厅高校科研项目(14C0141) |
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中文摘要: |
摘 要:[目的] 探讨胃癌组织中GSK3β和CyclinD1的表达及其临床意义。[方法] 采用免疫组织化学染色方法,检测胃组织芯片中(包括48例胃癌和对应正常胃组织及24例癌旁组织)GSK3β和CyclinD1蛋白的表达。[结果] GSK3β和CyclinD1在胃癌组织中的表达率分别为35.4%和45.8%;GSK3β在癌组织中的阳性表达率明显低于正常胃组织和癌旁组织(P<0.05),并与分化程度、组织学类型和淋巴结转移有关(P<0.05);CyclinD1在胃癌组织中的阳性表达率则明显高于正常胃组织和癌旁组织,差异具有统计学意义(χ2=20.664,P<0.05);CyclinD1的表达则与TNM分期和淋巴结转移相关(P<0.05)。GSK3β与CyclinD1蛋白的表达呈负相关性(r=-0.331,P<0.05)。[结论] GSK3β和CyclinD1在胃癌的进展、分化、浸润和转移中起重要作用,是判断胃癌生物学行为的良好指标。 |
英文摘要: |
Abstract:[Purpose] To investigate the expressions of glycogen synthase kinase 3 beta(GSK3β) and CyclinD1 proteins in gastric cancer and their clinical significance. [Methods] The expression of GSK3β and CyclinD1 proteins in gastric tissue array of 48 samples with gastric cancer,their corresponding normal gastric mucosa,24 samples of cancer adjacent tissues were detected immunohistochemically. [Results] The positive expression rates of GSK3β and CyclinD1 in gastric cancer were 35.4% and 45.8% respectively.The positive expression rate of GSK3β in cancer tissues was lower than that in normal tissues and cancer adjacent tissues(P<0.05),and it was correlated with differential grade,histological type and lymph node metastasis(P<0.05). The positive expression rate of CyclinD1 protein in cancer tissues was higher than that in normal tissues and cancer adjacent tissues (P<0.05),and it was correlated with TNM stage and lymph node metastasis (P<0.05). There was a negative correlation between the expressions of GSK3β and CyclinD1 in gastric cancer (r=-0.331,P<0.05).[Conclusion] GSK3β and CyclinD1 might play important roles in the progression,differentiation,invasion,lymph node metastasis of gastric cancer,and might be indicators for evaluating biologic behavior of gastric cancer. |
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