| 刘福学,夏青生,邱 杰.C-myb和p53在甲状腺乳头状癌中的表达及临床意义[J].肿瘤学杂志,2015,21(4):320-324. |
| C-myb和p53在甲状腺乳头状癌中的表达及临床意义 |
| Expressions of C-myb and p53 in Papillary Thyroid Cancer and Their Clinical Significance |
| 投稿时间：2014-12-23 |
| DOI：10.11735/j.issn.1671-170X.2015.04.B013 |
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| 中文关键词: C-myb p53 甲状腺肿瘤 乳头状癌 腺瘤 免疫组织化学 |
| 英文关键词:C-myb p53 thyroid neoplasms papillary carcinoma adenoma |
| 基金项目:青岛市科技局项目（13-1-4-166-jch） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨甲状腺乳头状癌中C-myb、p53的表达及其临床意义。［方法］ 采用免疫组化（SP）法研究38例甲状腺乳头状癌及癌旁组织，22例甲状腺瘤及腺瘤周围组织中C-myb、p53的表达。［结果］ C-myb在甲状腺乳头状癌组织、甲状腺腺瘤、癌旁组织及腺瘤周围组织中表达的阳性率分别为86.8%、63.6%、10.5%、4.5%；p53则分别为81.6%、22.7%、0、0。C-myb、p53蛋白在甲状腺乳头状癌、癌旁组织、甲状腺腺瘤及腺瘤周围组织中表达差异均有统计学意义（P<0.05）。［结论］ C-myb、p53在甲状腺组织中的异常表达与甲状腺乳头状癌发生发展相关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expressions of C-myb and p53 in papillary thyroid cancer(PTC) and their significance.［Methods］ Immunohistochemical staining(SP) was used to detect the expressions of C-myb and p53 in tissues of 38 cases with PTC and cancer adjacent，and 22 cases with adenoma and adenoma adjacent.［Results］ The positive expression rate of C-myb was 86.8%，63.6%，10.5% and 4.5% in PTC，adenoma，cancer adjacent tissues and adenoma adjacent tissues respectively，and that of p53 was 81.6%，22.7%，0 and 0 respectively. There was significant difference of C-myb or p53 among various thyroid tissues(P<0.05). ［Conclusion］ The abnormal expressions of C-myb and p53 in thyroid tissues play important roles in carcinogenesis of PTC. |
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