| 孙国贵,崔大为,程云杰.CCNG2在前列腺癌中的表达及其临床意义[J].肿瘤学杂志,2014,20(12):1018-1021. |
| CCNG2在前列腺癌中的表达及其临床意义 |
| Expression of CCNG2 in Prostate Cancer and Its Significance |
| 投稿时间：2014-01-16 |
| DOI：10.11735/j.issn.1671-170X.2014.12.B010 |
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| 中文关键词: CCNG2 前列腺肿瘤 预后 肿瘤转移 |
| 英文关键词:CCNG2 prostate neoplasms prognosis tumor metastasis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨细胞周期蛋白G2 (CCNG2) 在前列腺癌中的表达及意义。［方法］ 采用免疫组织化学方法、Western blot检测85例前列腺癌组织及距其癌组织边缘2cm以上镜下未见癌浸润的正常组织中CCNG2蛋白的表达情况。［结果］ 免疫组织化学结果表明，CCNG2蛋白在前列腺癌组织及正常前列腺组织中的表达阳性率分别为31.8%、96.5%，差异有统计学意义（P＜0.05）。Western blot结果表明，CCNG2蛋白在前列腺癌组织的相对表达量较正常前列腺组织的相对表达量明显降低，差异具有统计学意义（P＜0.05）。CCNG2蛋白表达与前列腺癌患者年龄、肿瘤大小、PSA水平无关（P＞0.05）；而与Gleason score、淋巴结转移以及肿瘤临床分期有关（P＜0.05）。［结论］ 前列腺癌组织中CCNG2蛋白表达明显降低，且与前列腺癌Gleason score、淋巴结转移、临床分期有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of Cyclin G2(CCNG2) in prostate carcinoma and its clinical significance. ［Methods］ Immunohistochemistry and Western blot were used to detect CCNG2 protein expression in 85 cases of prostate cancer and ≥2cm cancer adjacent normal tissues. ［Results］ Immunohistochemistry：the level of CCNG2 protein expression was significantly lower in prostate cancer tissues than that in normal tissues(P<0.05). Western blot：the relative amount of CCNG2 protein in prostate cancer tissues was significantly lower than that in normal tissues(P<0.05). The level of CCNG2 protein expression did not correlate with age，PSA contention and tumor size (P＞0.05)，but it correlated with lymph node metastasis，clinic stage and Gleason score(P<0.05). ［Conclusion］ Expression of CCNG2 downregulates in prostate cancer tissues and significantly correlates with lymph node metastasis，clinic stage and Gleason score. It suggests that CCNG2 may play an important role as a negative regulator to prostate cancer. |
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