| 王瑞海,崔大为,孙国贵.DMBT1在肾癌组织中的表达及其临床意义[J].肿瘤学杂志,2014,20(8):664-667. |
| DMBT1在肾癌组织中的表达及其临床意义 |
| Expression of DMBT1 in Kidney Cancer Tissues and Its Significance |
| 投稿时间：2013-12-17 |
| DOI：10.11735/j.issn.1671-170X.2014.08.B011 |
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| 中文关键词: DMBT1 肾肿瘤 预后 肿瘤转移 |
| 英文关键词:DMBT1 kidney neoplasms prognosis tumor metastasis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨脑恶性肿瘤缺失基因1 (DMBT1) 在肾癌组织中的表达及其意义。［方法］采用免疫组织化学方法检测47例肾癌组织及距其癌组织边缘2cm以上的镜下未见癌浸润的正常组织中DMBT1蛋白表达情况。［结果］ 免疫组织化学结果表明，DMBT1蛋白在肾癌组织及正常肾脏组织中的表达阳性率分别为31.9%、76.6%，差异有统计学意义（P＜0.05）。DMBT1蛋白表达与肾癌患者性别、年龄、肿瘤大小无关（P＞0.05）；而与细胞分化程度、淋巴结转移以及肿瘤临床分期有关（P＜0.05）。Kaplan-Meier生存分析提示，DMBT1表达阳性的肾癌患者5年总生存率明显高于表达阴性者，差异具有统计学意义（P＜0.05）。［结论］ 肾癌组织中DMBT1蛋白表达降低，且与肾癌细胞分化程度、淋巴结转移、临床分期及患者预后有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of deleted in malignant brain tumor 1 (DMBT1) in kidney carcinoma tissues and its clinical significance.［Methods］ Immunohistochemistry was used to detect DMBT1 protein expression of kidney cancer tissues and cancer adjacent tissues in 47 cases with kidney cancer.［Results］ The level of DMBT1 protein expression was significantly lower in kidney cancer tissues(31.9%) than that in cancer adjacent tissues(76.6%)(P<0.05). The level of DMBT1 protein expression did not correlate to gender，age and tumor size(P＞0.05)，but correlated to lymph node metastasis，clinic stage and histological grade(P<0.05). Kaplan-Meier analysis showed that loss of DMBT1 expression correlated significantly to poor overall survival. ［Conclusion］ DMBT1 expression decreases in kidney cancer tissue and correlates significantly to lymph node metastasis，clinic stage，histological grade and overall survival. |
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