王瑞海,崔大为,孙国贵.DMBT1在肾癌组织中的表达及其临床意义[J].肿瘤学杂志,2014,20(8):664-667. |
DMBT1在肾癌组织中的表达及其临床意义 |
Expression of DMBT1 in Kidney Cancer Tissues and Its Significance |
投稿时间:2013-12-17 |
DOI:10.11735/j.issn.1671-170X.2014.08.B011 |
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中文关键词: DMBT1 肾肿瘤 预后 肿瘤转移 |
英文关键词:DMBT1 kidney neoplasms prognosis tumor metastasis |
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中文摘要: |
摘 要:[目的] 探讨脑恶性肿瘤缺失基因1 (DMBT1) 在肾癌组织中的表达及其意义。[方法]采用免疫组织化学方法检测47例肾癌组织及距其癌组织边缘2cm以上的镜下未见癌浸润的正常组织中DMBT1蛋白表达情况。[结果] 免疫组织化学结果表明,DMBT1蛋白在肾癌组织及正常肾脏组织中的表达阳性率分别为31.9%、76.6%,差异有统计学意义(P<0.05)。DMBT1蛋白表达与肾癌患者性别、年龄、肿瘤大小无关(P>0.05);而与细胞分化程度、淋巴结转移以及肿瘤临床分期有关(P<0.05)。Kaplan-Meier生存分析提示,DMBT1表达阳性的肾癌患者5年总生存率明显高于表达阴性者,差异具有统计学意义(P<0.05)。[结论] 肾癌组织中DMBT1蛋白表达降低,且与肾癌细胞分化程度、淋巴结转移、临床分期及患者预后有关。 |
英文摘要: |
Abstract:[Purpose] To investigate the expression of deleted in malignant brain tumor 1 (DMBT1) in kidney carcinoma tissues and its clinical significance.[Methods] Immunohistochemistry was used to detect DMBT1 protein expression of kidney cancer tissues and cancer adjacent tissues in 47 cases with kidney cancer.[Results] The level of DMBT1 protein expression was significantly lower in kidney cancer tissues(31.9%) than that in cancer adjacent tissues(76.6%)(P<0.05). The level of DMBT1 protein expression did not correlate to gender,age and tumor size(P>0.05),but correlated to lymph node metastasis,clinic stage and histological grade(P<0.05). Kaplan-Meier analysis showed that loss of DMBT1 expression correlated significantly to poor overall survival. [Conclusion] DMBT1 expression decreases in kidney cancer tissue and correlates significantly to lymph node metastasis,clinic stage,histological grade and overall survival. |
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