| 陈 崇,周桃玉,温旺荣.乳腺癌组织中Ki67表达及其临床意义的Meta分析[J].肿瘤学杂志,2014,20(4):270-275. |
| 乳腺癌组织中Ki67表达及其临床意义的Meta分析 |
| Expression of Ki67 in Breast Cancer and Its Clinical Significance：A Meta-analysis |
| 投稿时间：2013-12-04 |
| DOI：10.11735/j.issn.1671-170X.2014.04.B002 |
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| 中文关键词: Ki67 乳腺肿瘤 Meta 分析 病例对照研究 |
| 英文关键词:Ki67 breast neoplasms Meta analysis case-control study |
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| 中文摘要: |
| 摘 要：［目的］系统评价国内有关乳腺癌组织中Ki67表达及其临床意义的病例对照研究。 ［方法］ 计算机检索CBM、CNKI、VIP 和万方数据库，并辅以文献追溯的方法，收集国内公开发表的所有关于乳腺癌组织中Ki67表达及其与临床病理特征关系的病例对照研究。检索年限均从建库至2013 年10月10 日。按纳入和排除标准筛选文献并评价纳入研究质量后，应用RevMan5.0和Stata12.0软件进行Meta 分析。［结果］ 共纳入12个病例对照研究，其中乳腺癌756 例，非乳腺癌1421 例。Meta 分析结果显示，Ki67 在乳腺癌组与非乳腺癌组（OR=6.01，95%CI：4.72~7.66）、乳腺癌临床Ⅰ～Ⅱ期组与Ⅲ～Ⅳ期组（OR=0.33，95%CI：0.18~0.61）、乳腺癌患者年龄≤35岁组与＞35岁组（OR=1.91，95%CI：1.37~2.66）的表达差异均有统计学意义；Ki67在乳腺癌有淋巴结转移组与无淋巴结转移组（OR=1.53，95%CI：0.98~2.39）表达差异则无统计学意义。［结论］ Ki67可能在乳腺癌中过度表达，其表达与乳腺癌的临床病理特征密切相关，对乳腺癌的早期诊断、治疗及预后判断具有重要意义，但其能否作为乳腺癌诊断及预后的可靠指标尚不确定，需要进行更多设计严谨、细致的高质量流行病学研究来进一步证实。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the case-control studies addressing the expression and clinical significance of Ki67 in human breast cancer with meta-analysis. ［Methods］ A computer-based retrieval of CBM，VIP，CNKI and Wanfang Database was performed from their establishment to October 2013 for case-control studies investigating the Ki67 expression and clinical significance in breast cancer. The quality of the included studies was assessed. The data were analyzed by RevMan5.0 and Stata12.0 softwares.［Results］ A total of 12 studies were recruited. As for the positive rate of Ki67，significant differences were tested between breast cancer group vs normal breast tissues group，breast cancer clinical stages Ⅰ~Ⅱgroup vs Ⅲ~Ⅳ group，breast cancer ≤35 years old group vs ＞35 years old group with OR(95%CI) at 6.01 (4.72~7.66)，0.33(0.18~0.61) and 1.91(1.37~2.66)，respectively. No significant difference was tested between lymph node metastasis group vs non-lymph node metastasis group with OR(95%CI) at 1.53(0.98~2.39).［Conclusion］ According to the domestic evidence，Ki67 may be participated the whole course of carcinogenesis of breast cancer，which might be valuable for the early diagnosis，treatment and prognosis，but is not the absolute factor for estimating the survival rate of the patients with breast cancer，and more high-quality studies are expected for further study. |
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