| 余德洪,韩国平,赵永华.磁共振弥散加权成像对脊柱转移瘤放疗疗效的评估[J].肿瘤学杂志,2014,20(2):144-147. |
| 磁共振弥散加权成像对脊柱转移瘤放疗疗效的评估 |
| Evaluation of Diffusion Weighted Imaging on Radiotherapeutic Effect of Spinal Metastatic Tumors |
| 投稿时间：2013-09-12 |
| DOI：10.11735/j.issn.1671-170X.2014.02.B014 |
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| 中文关键词: 弥散加权成像 表观弥散系数 脊柱转移瘤 |
| 英文关键词:diffusion weighted imaging apparent diffusion coefficient spinal metastatic tumor |
| 基金项目:杭州市医药卫生科技基金（2012B046） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨磁共振弥散加权成像（DWI）对脊柱转移瘤放疗疗效的评估价值。［方法］ 收集30例脊柱转移瘤患者放疗前、后2个月的磁共振图像，所有患者均进行常规MRI及DWI序列。比较常规MRI序列与DWI序列对病灶的检出率。同时对照分析30例患者放疗前、后的DWI信号、ADC值。［结果］ 放疗前常规MRI扫描共发现病灶48个，累及42个椎体。DWI序列发现病灶56个，累及48个椎体。放疗结束后2个月复查MRI，SE T1WI上脊柱转移瘤信号不变或略有下降。FSE T2WI上20例信号轻度下降，10例不变。而在临床症状有改善的26例病例中，相对于放疗前，转移瘤DWI信号明显降低。在b=650s/mm2的DWI中，脊柱转移瘤放疗前表观扩散系数（ADC）值为（0.72±0.21）×10-3mm2/s，放疗后ADC值升高到（1.32±0.22）×10-3mm2/s；相邻正常椎体骨髓的ADC值较转移瘤低，且放疗前后没有变化。［结论］ DWI序列既可以提高MRI对脊柱转移瘤的检出率，也可以用于监测和评估脊柱转移瘤的放疗疗效。 |
| 英文摘要: |
| Abstract：［Purpose］ To study the effect of diffusion weighted imaging on the radiotherapy for spinal metastatic tumors. ［Methods］ The MR imaging in 30 patients with spinal metastatic tumor were enrolled. Before and two months after radiotherapy，all cases were scanned by conventional sequences and DWI.The detection rate of conventional sequences and DWI was analyzed. The DWI signals and ADC value before and after radiotherapy were compared. ［Results］ Forty-eight lesions involved 42 centrums were detected by conventional sequences；Fifty-six lesions involoved 48 centrums were detected by DWI. Two months after radiotherapy，the signals of spinal metastatic tumors demonstrated unchange or slight decrease on SE-T1WI；20 cases demonstrated slight decrease and 10 cases demonstrated unchange on FSE-T2WI.In 26 patients with clinical symptom improved，the metastatic tumors demonstrated decrease obviously on DWI. The ADC values of spinal metastatic tumors were （0.72±0.21）×10-3mm2/s on the images of pre-radiotherapeutic DWI(b=650s/mm2). Two months after radiotherapy，the ADC values were（1.32±0.22）×10-3mm2/s. The ADC value of normal centrums was lower than that of metastatic tumors and unchanged before and after radiation.［Conclusion］ DWI sequence is not only able to improve the detection rate of spinal metastases，but also be used for monitoring and evaluating radiotherapeutic effect for spinal metastatic tumor. |
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