王瑞海,崔大为,翟宏芳.DMBT1在乳腺癌组织中的表达及临床意义[J].肿瘤学杂志,2014,20(2):102-105.
DMBT1在乳腺癌组织中的表达及临床意义
Expression of DMBT1 in Breast Cancer Tissue and Its Clinical Significance
投稿时间:2013-09-10  
DOI:10.11735/j.issn.1671-170X.2014.02.B005
中文关键词:  DMBT1  乳腺肿瘤  预后  肿瘤转移
英文关键词:DMBT1  breast neoplasms  prognosis  metastasis
基金项目:
作者单位
王瑞海 唐山市开平区医院 
崔大为 唐山市工人医院 
翟宏芳 唐山市人民医院 
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中文摘要:
      摘 要: [目的] 探讨脑恶性肿瘤缺失基因1 (DMBT1) 在乳腺癌组织中的表达及意义。[方法] 采用免疫组织化学方法检测73例乳腺癌组织及距其癌组织边缘2cm以上镜下未见癌浸润的正常组织中DMBT1蛋白的表达情况。[结果] 免疫组织化学结果表明,DMBT1蛋白在乳腺癌组织及正常乳腺组织中的表达阳性率分别为35.6%、70.9%,差异有统计学意义(P<0.05)。DMBT1蛋白表达与T分期、分化程度、淋巴结转移以及临床分期有关(P<0.05)。Kaplan-Meier生存分析提示,DMBT1表达阳性的乳腺癌患者5年总生存率明显高于表达阴性者,两者比较差异具有统计学意义(P<0.05)。[结论] 乳腺癌组织中DMBT1蛋白表达降低,且与乳腺癌T分期、分化程度、淋巴结转移、临床分期及患者预后有关。
英文摘要:
      Abstract:[Purpose] To investigate the expression of deleted in malignant brain tumor 1 (DMBT1) in breast carcinoma tissues and its significance. [Methods] Immunohistochemistry was used to detect DMBT1 protein expression in 73 cases of breast cancer tissues and 31 cases of normal tissues. [Results] The level of DMBT1 protein expression was significantly lower in breast cancer tissues than that in normal tissues (P<0.05). The level of DMBT1 protein expression correlated to T stage,lymph node metastasis,clinic stage and histological grade(P<0.05). Loss of DMBT1 expression correlated significantly to poor overall survival by Kaplan-Meier analysis. [Conclusion] DMBT1 expression decreases in breast cancer tissues and correlates to T stage,lymph node metastasis,clinic stage,histological grade and overall survival,suggesting that DMBT1 may play an important role in breast cancer.
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