| 王瑞海,崔大为,翟宏芳.DMBT1在乳腺癌组织中的表达及临床意义[J].肿瘤学杂志,2014,20(2):102-105. |
| DMBT1在乳腺癌组织中的表达及临床意义 |
| Expression of DMBT1 in Breast Cancer Tissue and Its Clinical Significance |
| 投稿时间：2013-09-10 |
| DOI：10.11735/j.issn.1671-170X.2014.02.B005 |
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| 中文关键词: DMBT1 乳腺肿瘤 预后 肿瘤转移 |
| 英文关键词:DMBT1 breast neoplasms prognosis metastasis |
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| 中文摘要: |
| 摘 要： ［目的］ 探讨脑恶性肿瘤缺失基因1 (DMBT1) 在乳腺癌组织中的表达及意义。［方法］ 采用免疫组织化学方法检测73例乳腺癌组织及距其癌组织边缘2cm以上镜下未见癌浸润的正常组织中DMBT1蛋白的表达情况。［结果］ 免疫组织化学结果表明，DMBT1蛋白在乳腺癌组织及正常乳腺组织中的表达阳性率分别为35.6%、70.9%，差异有统计学意义（P＜0.05）。DMBT1蛋白表达与T分期、分化程度、淋巴结转移以及临床分期有关（P＜0.05）。Kaplan-Meier生存分析提示，DMBT1表达阳性的乳腺癌患者5年总生存率明显高于表达阴性者，两者比较差异具有统计学意义（P＜0.05）。［结论］ 乳腺癌组织中DMBT1蛋白表达降低，且与乳腺癌T分期、分化程度、淋巴结转移、临床分期及患者预后有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of deleted in malignant brain tumor 1 (DMBT1) in breast carcinoma tissues and its significance. ［Methods］ Immunohistochemistry was used to detect DMBT1 protein expression in 73 cases of breast cancer tissues and 31 cases of normal tissues. ［Results］ The level of DMBT1 protein expression was significantly lower in breast cancer tissues than that in normal tissues (P<0.05). The level of DMBT1 protein expression correlated to T stage，lymph node metastasis，clinic stage and histological grade(P<0.05). Loss of DMBT1 expression correlated significantly to poor overall survival by Kaplan-Meier analysis. ［Conclusion］ DMBT1 expression decreases in breast cancer tissues and correlates to T stage，lymph node metastasis，clinic stage，histological grade and overall survival，suggesting that DMBT1 may play an important role in breast cancer. |
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