| 詹建伟,姜支农,焦德敏.丝切蛋白在非小细胞肺癌中的表达及其临床意义[J].肿瘤学杂志,2014,20(1):47-50. |
| 丝切蛋白在非小细胞肺癌中的表达及其临床意义 |
| Expression of Cofilin in Non-small Cell Lung Cancer and Its Clinical Significance |
| 投稿时间：2013-08-29 |
| DOI：10.11735/j.issn.1671-170X.2014.01.B010 |
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| 中文关键词: 癌，非小细胞肺 丝切蛋白 肿瘤转移 |
| 英文关键词:carcinoma,non-small cell lung cofilin neoplasm metastasis |
| 基金项目:杭州市卫生局医药卫生科技计划项目(2010B039) |
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| 中文摘要: |
| 摘 要：［目的］ 探讨丝切蛋白（cofilin）在非小细胞肺癌（NSCLC）组织和不同转移潜能肺癌细胞系中的表达及其临床意义。［方法］ 应用Western blot法检测肺癌细胞系中cofilin蛋白的表达水平。并采用免疫组织化学SP法检测100例NSCLC组织及３０例癌旁正常组织中cofilin的表达。［结果］ 高转移性肺癌细胞系中cofilin 蛋白的表达明显高于低转移性肺癌细胞系。100例NSCLC组织中，cofilin的阳性表达率为65%。cofilin蛋白的表达与NSCLC患者的性别、年龄、肿瘤大小、组织类型、临床分期以及病理分级均无关（P均＞0.05），仅与有无淋巴结转移有关(P＜0.01)。［结论］ cofilin蛋白在NSCLC的生长和转移过程中发挥着重要的调控作用，可作为判断NSCLC转移的重要生物学指标。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of cofilin in human non- small cell lung cancer tissues(NSCLC) and lung cancer cell lines，and its clinical significance with cancerous metastasis. ［Methods］ The expression of cofilin protein in lung cancer cell line was detected by Western blot. Cofilin was detected by immuno- histochemical staining SP technique in tumor tissues from 100 lung cancer cases and in carcinoma adjacent tissues from 30 patients.［Results］ The expression of cofilin protein up-regulated in highly metastatic human lung cancer. The positive rate of cofilin expression in 100 lung cancer cases was 65%. The up-regulation of cofilin expression significantly correlated with lymph node metastasis，but did not correlate with age，sex，tumor size，histological type，TNM stage and pathological grading.［Conclusion］ Cofilin probably plays an important regulating role in the growth and metastasis of lung cancer. Detection of cofilin expression can help in evaluating the metastasis of non-small cell lung cancer. |
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