| 王亚军,周 航,刘 霄.手术联合放、化疗与单纯手术治疗Ⅰa~Ⅱa期宫颈鳞癌患者的疗效比较[J].肿瘤学杂志,2013,19(12):970-972. |
| 手术联合放、化疗与单纯手术治疗Ⅰa~Ⅱa期宫颈鳞癌患者的疗效比较 |
| Comparison of Clinical Effects of Radical Surgery Combined with Chemoradiotherapy and Radical Surgery Alone in the Treatment for Cervical Squamous Cell Carcinoma StageⅠa~Ⅱa |
| 投稿时间：2013-09-27 |
| DOI：10.11735/j.issn.1671-170X.2013.12.B013 |
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| 中文关键词: 手术联合放、化疗 单纯手术治疗 宫颈肿瘤 局部复发 远处转移 |
| 英文关键词:operative chemoradiotherapy radical surgery alone cervical squamous cell carcinoma local recurrence distant metastases |
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| 中文摘要: |
| 摘 要：［目的］ 观察宫颈癌根治术联合放、化疗治疗Ⅰa~Ⅱa期宫颈鳞癌患者的临床疗效，并与单纯根治手术疗效进行比较。［方法］ 采用回顾性分析方法，将2007年1月至2012年7月期间收治的经根治手术治疗并具有复发、转移高危因素的94例Ⅰa~Ⅱa期宫颈鳞癌患者的临床相关资料进行整理、分析，其中63例患者宫颈癌根治术后3~5个月内行盆腔外放疗加TP方案全身化疗2~4周期；另外31例患者仅行单纯宫颈癌根治手术治疗，对两组患者的临床疗效进行比较分析。［结果］ 随访时间为12~79个月，中位随访37个月，随访期内，手术联合放、化疗组与单纯手术组的盆腔或阴道残端局部复发率分别为3.17%和 61.29%，远处脏器或组织转移率分别为17.46%和51.61%，差异均有显著统计学意义（P＜0.05）。［结论］ 对于Ⅰa~Ⅱa期宫颈鳞癌根治性手术后具有复发、转移高危因素的患者，术后联合放、化疗能明显降低其局部复发率及远处转移率，具有较高的临床应用价值。 |
| 英文摘要: |
| Abstract：［Purpose］ To compare clinical effects of radical surgery combined with chemoradiotherapy and radical surgery alone in the treatment for cervical squamous cell carcinoma stageⅠa~Ⅱa. ［Methods］ Ninety-four cases with cervical squamous cell carcinoma stageⅠa~Ⅱa were enrolled and analyzed retrospectively. Of 94 cases，63 cases treated with radical surgery combined with chemoradiotherapy(pelvic radiotherapy plus TP regimen chemotherapy 2~4 cycles)，while 31 cases treated with radical surgery alone.［Results］ The time of follow-up was 12~79 months，with a median follow-up of 37 months.The pelvic or vaginal stump recurrence rates of radical surgery combined with chemoradiotherapy group and surgery alone group were 3.17% and 61.29%，distant or local metastasis rates were 17.46% and 51.61% respectively，with significant difference(P<0.05). ［Conclusion］ Radical surgery combined with chemoradiotherapy in the treatment for cervical squamous cell carcinoma stageⅠa~Ⅱa is able to improve local recurrence and distant metastasis rate，with a high clinical value. |
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