| 刘营营,王 宇,韩桂萍.Toll样受体4与炎性肠病和结肠癌[J].肿瘤学杂志,2013,19(9):735-738. |
| Toll样受体4与炎性肠病和结肠癌 |
| Toll-like Receptor 4 in Inflammatory Bowel Disease and Colon Cancer |
| 投稿时间：2013-04-07 |
| DOI：10.11735/j.issn.1671-170X.2013.09.B016 |
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| 中文关键词: Toll样受体4 炎性肠病 结肠肿瘤 |
| 英文关键词:Toll-like receptor 4 inflammatory bowel disease colorectal neoplasms |
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| 中文摘要: |
| 摘 要:Toll样受体（TLR）是天然免疫中重要的模式识别受体，主要在免疫细胞上表达，能特异性地识别病原相关分子模式，并在启动和调节天然免疫及获得性免疫中起到重要作用。研究表明TLR4在炎性肠病和结肠癌中表达增高。文章主要综述TLR4在结肠癌及炎性肠病癌变过程中的作用。 |
| 英文摘要: |
| Abstract:Toll-like receptors ( TLRs ) are the important pattern recognition receptors (PRR) in innate immunity，located on the cell surface，and can identify the pathogen associated molecular patterns(PAMPs )specificity. TLRs play an important role in in the initiation and regulation of innate immunity and acquired immunity. Studies suggest that TLR4 expression increase in inflammatory bowel disease (IBD) and colorectal cancer. The role of TLR4 in colon cancer and carcinogenesis of IBD are reviewed. |
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