| 李志雄,林杰成,吴 宁.食管鳞状细胞癌ID-2的表达及其与新生血管生成的关系[J].肿瘤学杂志,2013,19(9):704-708. |
| 食管鳞状细胞癌ID-2的表达及其与新生血管生成的关系 |
| Expression of ID-2 Protein in Esophageal Squamous Cell Carcinoma (ESCC) and Its Relationship with Tumor Angiogenesis |
| 投稿时间：2013-06-10 |
| DOI：10.11735/j.issn.1671-170X.2013.09.B009 |
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| 中文关键词: 食管肿瘤 分化抑制因子-2（ID-2） 血管生成 免疫组织化学 |
| 英文关键词:esophageal neoplasms inhibitors of DNA binding-2 angiogenesis immunohistochemistry |
| 基金项目:莆田市2009年科研立项项目［2009S09（2-1）］ |
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| 中文摘要: |
| 摘 要：［目的］ 通过观察ID-2在食管鳞癌（ESCC）中的表达及其与微血管密度(MVD)的关系，探讨 ID-2在ESCC发生及血管生成中的作用。［方法］ 应用SP法对115例ESCC组织、60例切缘正常组织进行ID-2免疫组化染色，检测癌组织、正常食管黏膜组织中ID-2的表达，并分析ID-2的表达与ESCC临床病理特征及与MVD之间的关系。［结果］ ID-2在ESCC组织中的阳性表达率为85.2%（98/115），切缘正常组织中阳性率15.0% （9/60），两者差异有统计学意义（P<0.01），其表达与患者年龄、性别及是否伴淋巴结转移均无关（P＞0.05），而与肿瘤浸润深度、MVD、肿瘤分期以及肿瘤分化程度有关（P<0.05)。ID-2高表达组术后生存率低（P<0.05)。［结论］ ID-2在ESCC的发生及血管生成中起重要作用，可能是ESCC的重要促血管生成因子之一，ID-2蛋白高表达者ESCC患者预后差。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expression of ID-2 protein in esophageal squamous cell carcinoma (ESCC) and its relationship with tumor angiogenesis.［Methods］ The expression of ID-2 in 115 cases of surgical resected ESCC tissue specimens and 60 negative margin tissues as control were examined by SP immunohistochemical staining. The relationships of the expression of ID-2 with carcinogensis of esophageal squamous cell carcinoma and MVD were analyzed. ［Results］ The positive expression rate of ID-2 was 85.2%(98/115) in ESCC tissues and 15.0% (9/60) in negative margin tissues，with significantly different (P<0.01). The expression of ID-2 related to depth of tumor invasion，MVD，tumor stage and differentiation(P<0.05)，but didn’t relate to the age，gender，depth of invasion and lymphatic metastasis(P＞0.05). High expression of ID-2 had a worse prognosis (P<0.05). ［Conclusion］ Expression of ID-2 plays an important role in tumorigenesis，tumor angiogenesis in ESCC. ID-2 may be one of important agents in promoting tumor angiogenesis in ESCC. High expression of ID-2 may shorten survival. |
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