李志雄,林杰成,吴 宁.食管鳞状细胞癌ID-2的表达及其与新生血管生成的关系[J].肿瘤学杂志,2013,19(9):704-708. |
食管鳞状细胞癌ID-2的表达及其与新生血管生成的关系 |
Expression of ID-2 Protein in Esophageal Squamous Cell Carcinoma (ESCC) and Its Relationship with Tumor Angiogenesis |
投稿时间:2013-06-10 |
DOI:10.11735/j.issn.1671-170X.2013.09.B009 |
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中文关键词: 食管肿瘤 分化抑制因子-2(ID-2) 血管生成 免疫组织化学 |
英文关键词:esophageal neoplasms inhibitors of DNA binding-2 angiogenesis immunohistochemistry |
基金项目:莆田市2009年科研立项项目[2009S09(2-1)] |
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中文摘要: |
摘 要:[目的] 通过观察ID-2在食管鳞癌(ESCC)中的表达及其与微血管密度(MVD)的关系,探讨 ID-2在ESCC发生及血管生成中的作用。[方法] 应用SP法对115例ESCC组织、60例切缘正常组织进行ID-2免疫组化染色,检测癌组织、正常食管黏膜组织中ID-2的表达,并分析ID-2的表达与ESCC临床病理特征及与MVD之间的关系。[结果] ID-2在ESCC组织中的阳性表达率为85.2%(98/115),切缘正常组织中阳性率15.0% (9/60),两者差异有统计学意义(P<0.01),其表达与患者年龄、性别及是否伴淋巴结转移均无关(P>0.05),而与肿瘤浸润深度、MVD、肿瘤分期以及肿瘤分化程度有关(P<0.05)。ID-2高表达组术后生存率低(P<0.05)。[结论] ID-2在ESCC的发生及血管生成中起重要作用,可能是ESCC的重要促血管生成因子之一,ID-2蛋白高表达者ESCC患者预后差。 |
英文摘要: |
Abstract:[Purpose] To investigate the expression of ID-2 protein in esophageal squamous cell carcinoma (ESCC) and its relationship with tumor angiogenesis.[Methods] The expression of ID-2 in 115 cases of surgical resected ESCC tissue specimens and 60 negative margin tissues as control were examined by SP immunohistochemical staining. The relationships of the expression of ID-2 with carcinogensis of esophageal squamous cell carcinoma and MVD were analyzed. [Results] The positive expression rate of ID-2 was 85.2%(98/115) in ESCC tissues and 15.0% (9/60) in negative margin tissues,with significantly different (P<0.01). The expression of ID-2 related to depth of tumor invasion,MVD,tumor stage and differentiation(P<0.05),but didn’t relate to the age,gender,depth of invasion and lymphatic metastasis(P>0.05). High expression of ID-2 had a worse prognosis (P<0.05). [Conclusion] Expression of ID-2 plays an important role in tumorigenesis,tumor angiogenesis in ESCC. ID-2 may be one of important agents in promoting tumor angiogenesis in ESCC. High expression of ID-2 may shorten survival. |
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