徐志远,程向东,杜义安.ZIP4蛋白在胃癌中的表达及其临床意义[J].肿瘤学杂志,2013,19(6):476-479. |
ZIP4蛋白在胃癌中的表达及其临床意义 |
Expression of ZIP4 Protein in Gastric Cancer and Its Clinical Significance |
投稿时间:2013-03-27 |
DOI:10.11735/j.issn.1671-170X.2013.06.B014 |
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中文关键词: 胃肿瘤;ZIP4 预后 免疫组织化学 |
英文关键词:gastric neoplasms ZIP4 prognosis immunohistochemistry |
基金项目:浙江省自然科学基金(LY12H16029,LY13H160027); 浙江省中医药重点研究计划(2012ZZ002)。 |
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中文摘要: |
摘 要:[目的] 研究ZIP4蛋白在胃癌中的表达并分析其临床意义。[方法] 免疫组化检测70例手术切除胃癌组织及相应癌旁组织标本中ZIP4的表达,并分析其与患者临床病理特征及预后的关系。[结果] 胃癌及癌旁组织中ZIP4阳性表达率分别为52.9%(37/70)及92.9%(65/70)。与癌旁组织相比,68.6%(48/70)病人的胃癌组织中ZIP4表达明显下降;ZIP4的表达水平与患者的性别、年龄、 肿瘤大小、 部位、浸润深度、淋巴结转移均无相关性(P>0.05),而与肿瘤的Lauren’s分型、TNM分期明显有关(P<0.05);单因素及多因素分析均显示,肿瘤侵犯深度、淋巴结转移、Lauren’s分型、TNM分期及ZIP4表达水平是影响胃癌预后的独立危险因素(P<0.05),ZIP4低表达组患者5年生存率明显降低。[结论] ZIP4表达水平与胃癌Lauren’s分型、临床分期及预后密切相关,可作为判断胃癌生物学行为和预后的重要参考指标。 |
英文摘要: |
Abstract:[Purpose] To investigate the expression of ZIP4 protein in gastric cancer and its clinical significance.[Methods] Expressions of ZIP4 protein in cancer tissues and cancer adjacent tissues were detected immunohistochemically in 70 cases with gastric cancer,and their relationships with clinicopathological features and prognosis were analyzed.[Results] The positive rates of ZIP4 expression in gastric cancer tissues and cancer adjacent tissues were 52.9%(37/70) and 92.9%(65/70) respectively. Lower expression of ZIP4 in gastric cancer tissue than that in cancer adjacent tissues was found in 68.6%(48/70) of patients. Expression of ZIP4 did not correlate to age,gender,tumor size,location,invasive depth or lymph nodes metastasis(P>0.05),but correlated to the Lauren’s type and TNM staging(P<0.05). Both univariate or multivariate analysis revealed that invasive depth,lymph nodes metastasis,Lauren’s type,TNM stage and ZIP4 expression were independent predictors of prognosis(P<0.05). Patients with lower ZIP4 expression resulted worse 5-year survival. [Conclusion] Expression of ZIP4 in gastric cancer relates to the Lauren’s type,clinical stage and prognosis,and it might be useful to evaluate the biological behavior and prognosis for gastric cancer. |
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