| 伍方财,陈创珍,陈志坚.食管癌放射性食管炎相关因素的前瞻性研究[J].肿瘤学杂志,2013,19(3):202-205. |
| 食管癌放射性食管炎相关因素的前瞻性研究 |
| A Prospective Study of Related Factors of Radiation-induced Acute Esophagitis in Patients with Esophageal Cancer |
| 投稿时间：2012-12-31 |
| DOI：10.11735/j.issn.1671-170X.2013.03.B2012648 |
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| 中文关键词: 急性食管炎 食管肿瘤 三维适形放射治疗 |
| 英文关键词:acute esophagitis esophageal neoplasms three-dimensional conformal radiotherapy |
| 基金项目:汕头市重点科技计划项目（汕府科〔2009〕85号） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨食管癌三维适形放疗（3D-CRT）中放射性食管炎发生的相关危险因素。［方法］前瞻性观察2007年2月至2008年6月收治的37例病理确诊食管癌患者，全组患者接受根治性3D-CRT，其中29例接受同期化疗。每周记录食管炎RTOG分级至放疗结束后4周，并计算出食管炎指数（EI）作为评价放射性食管炎程度的标准。采用单因素分析食管炎相关因素，观察的因素包括患者年龄、性别、食管病灶部位、食管病灶长度、临床靶区（CTV）长度、食管受照射处方剂量、是否合并化疗和治疗前进食情况。［结果］ 根据RTOG标准，全组37例患者中发生0、1、2、3、4度食管炎分别为 7、13、15、1、1例，相应的EI为0～18，平均值为7.6。单因素分析显示，EI随食管病灶长度增长而增加，其差异有统计学意义（P=0.027）；合并化疗组EI也大于单纯放疗组，其差异有统计学意义（P=0.017）。未发现EI值和其他因素存在统计学关系。［结论］ 食管病灶长度和合并化疗是导致食管癌放射性食管炎的危险因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the risk factors of radiation-induced acute esophagitis (AE) in esophageal cancer patients treated with 3-dimensional conformal radiotherapy(3D-CRT). ［Methods］ From February 2007 to June 2008，37 patients with esophageal cancer pathologically proven were observed prospectively. All patients treated with 3D-CRT and 29 cases of them received concurrent chemotherapy (CCT). AE was graded every week for each patient according to the Radiation Therapy Oncology Group（RTOG）criteria from the first day of radiotherapy to 4 weeks after the end of radiotherapy. At the same time，we calculated esophagitis index (EI) to evaluate AE grade. The factors associated with AE including age and gender of patients，tumor position and length of the lesion，length of clinical target volume(CTV)，prescription dose，whether combined with chemotherapy (CCT) and diet of patients before treatment，which were analyzed by univariate analysis. ［Results］ According to RTOG criteria，The number of patients with AＥ grade 0，1，2，3，4 happened in 7，13，15，1 and 1 cases，respectively. EI scores for these 37 patients were 0~18，with an average value of 7.6. Univariate analyse showed that length of the lesion and CCT associated with EI，with significant difference(P=0.027，P=0.017). While other factors unrelated to radiation-induced acute esophagitis.［Conclusions］ The length of esophageal lesion and CCT are risk predictors of AE in esophageal cancer patients treated with 3D-CRT. |
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