| 栗子芳,宾 翔,周 永.诱导型一氧化氮合酶在鼻咽癌中表达及意义的Meta分析[J].肿瘤学杂志,2013,19(3):166-170. |
| 诱导型一氧化氮合酶在鼻咽癌中表达及意义的Meta分析 |
| Expression of Inducible Nitric Oxide Synthase in Nasopharyngeal Carcinoma and Its Significance: A Meta?鄄analysis |
| 投稿时间：2012-12-07 |
| DOI：10.11735/j.issn.1671-170X.2013.03.B2012600 |
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| 中文关键词: 诱导型一氧化氮合酶 Meta分析 鼻咽肿瘤 |
| 英文关键词:inducible nitric oxide synthase Meta?鄄analysis nasopharyngeal neoplasms |
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| 中文摘要: |
| 摘 要：［目的］ 系统评价诱导型一氧化氮合酶（iNOS）在鼻咽癌（NPC）组织中的表达及其临床意义。［方法］ 电子检索Pubmed、Embase、Cochrane、CBM、CNKI、VIP和万方数据库，收集有关iNOS在鼻咽癌组织中的表达及其与临床特征关系的病例对照研究。用Stata9.2统计软件包进行Meta分析。［结果］ 共纳入病例对照研究8篇，合计研究对象502例。Meta分析结果显示，iNOS在鼻咽癌组织的表达高于正常鼻咽黏膜组织（OR=27.42，95%CI：13.51~55.64)；在鼻咽癌组织中，有淋巴结转移者的iNOS表达高于无淋巴结转移者（OR=2.39，95%CI：1.33~4.30)，低T分期者的iNOS表达低于高T分期者（OR=0.30，95%CI：0.14~0.64)；而在不同年龄及性别中iNOS的表达差异无统计学意义。［结论］ iNOS在鼻咽癌组织中呈高表达，并与淋巴结转移和T分期关联密切，提示其过度表达与鼻咽癌的发生、发展、浸润和转移密切相关。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the expression of inducible nitric oxide synthase (iNOS) in nasopharyngeal carcinoma (NPC) tissues and its clinical significance. ［Methods］ Case-control studies of the expression of iNOS in nasopharyngeal carcinoma tissues were searched from Pubmed，Embase，Cochrane，CBM，CNKI，VIP and WanFang databases. Meta-analysis was done using STATA 9.2. ［Results］ A total of 8 papers with 502 cases were included. Meta-analysis showed that as the positive rate of iNOS expression，significant difference was found between the NPC tissues and the control tissues (OR=27.42，95%CI:13.51~55.64). Higher expression was detected in NPC tissues with lymph node metastasis group than that in NPC tissues without lymph node metastasis group(OR=2.39，95%CI:1.33~4.30)，while higher expression was detected in high T group than that in low T group (OR=0.30，95%CI:0.14~0.64)，but no significance difference was found for age and sex. ［Conclusion］ NPC tissue has high iNOS expression，and it strongly relates to the lymph node metastasis and T staging. The over expression of iNOS may be relative to the carcinogenesis，progress，invasion and metastasis of NPC. |
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