| 吴红卫,高立冬,卫广辉.散发性结直肠癌中hMSH2和nm23的表达及临床意义[J].肿瘤学杂志,2013,19(5):382-385. |
| 散发性结直肠癌中hMSH2和nm23的表达及临床意义 |
| Expression of hMSH2 and nm23 Proteins in Sporadic Colorectal Carcinoma and Their Clinical Significances |
| 投稿时间：2012-10-24 |
| DOI：10.11735/j.issn.1671-170X.2013.05.B2012458 |
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| 中文关键词: 结直肠肿瘤 hMSH2 nm23 预后 免疫组织化学 |
| 英文关键词:colorectal neoplasms hMSH2 nm23 prognosis immunohistochemistry |
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| 中文摘要: |
| 摘 要：［目的］ 研究错配修复蛋白hMSH2和nm23在散发性结直肠癌中的表达及两者之间的关系，并探讨其临床意义。［方法］ 采用SP免疫组织化学法检测87例结直肠癌组织中hMSH2和nm23蛋白的表达，分析两者的相关性，并结合随访资料进行生存分析。［结果］ 在散发性结直肠癌组织中，nm23蛋白表达与组织学类型无关(P>0.05)，与浸润深度、淋巴结转移相关(P<0.05)。hMSH2蛋白表达与组织学类型、浸润深度、淋巴结转移未见明显相关(P>0.05)。hMSH2与nm23蛋白表达在散发性结直肠癌中呈正相关(rs=0.635，P<0.05)。两者联合表达与散发性结直肠癌浸润深度、淋巴结转移及预后相关(P均<0.05)。［结论］ nm23蛋白水平与散发性结直肠癌恶性程度有关，可作为预测浸润转移潜能的一项指标。hMSH2与nm23蛋白表达呈正相关，两者联合检测对散发性结直肠癌预后的预测有一定指导意义。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression levels of mismatch repair protein hMSH2 and nm23 in sporadic colorectal cancer，and their clinical significance.［Methods］ The expressions of hMSH2 and nm23 protein in 87 cases of colorectal cancer tissues were detected by immunohistochemistry SP method. The correlation between expression of hMSH2 and nm23 was analyzed，also the follow-up data was used for survival analysis. ［Results］ The expression of nm23 protein in sporadic colorectal cancer tissues had no relationship with histological type(P>0.05)，but correlated with depth of invasion and lymph node metastasis(P<0.05). No significant correlation was observed between hMSH2 protein expression and pathological features(P>0.05). There was a positive correlation between the hMSH2 and nm23 protein expression in sporadic colo-rectal cancer(rs=0.635，P<0.05). The combined expression of hMSH2 and nm23 in sporadic colo-rectal cancer correlated with depth of invasion，lymph node metastasis and prognosis(P<0.05).［Conclusions］ nm23 protein expression level correlates with degree of malignancy of sporadic colorectal cancer，may be used as an indicator of invasive and metastatic potential. hMSH2 and nm23 protein expression are positively correlated，the combined expression has certain guiding significance for the prognosis of sporadic colorectal cancer. |
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