| 应莉莎,顾琳慧,杜灵彬.Reg IV与胃癌腹腔转移的相关性研究[J].肿瘤学杂志,2012,18(4):241-245. |
| Reg IV与胃癌腹腔转移的相关性研究 |
| The Correlation of Reg IV with Peritoneal Metastasis in Gastric Cancer |
| 投稿时间：2012-03-26 |
| DOI： |
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| 中文关键词: 胃肿瘤 Reg IV CA72-4 CK20 腹腔转移 |
| 英文关键词:gastric neoplasms Reg IV CA72-4 CK20 peritoneal metastasis |
| 基金项目:浙江省科技厅分析测试科技计划项目（2008F70024）；浙江省医药卫生科技计划项目（2009B029） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨Reg IV 表达与胃癌腹腔转移的相关性。［方法］ 利用实时荧光定量PCR检测50例胃癌患者腹腔冲洗液中Reg IV、CA72-4、CK20 的表达水平。［结果］ 病理诊断已明确发生腹腔转移的12例胃癌腹腔冲洗液中Reg IV的相对表达量为34.3（26.2~39.6），显著高于38例未发生腹腔转移的Reg IV的相对表达量22.7（18.4~33.0）（P=0.017）。Reg IV表达水平与患者淋巴结转移、淋巴管侵犯、临床分期等密切相关。淋巴结转移和淋巴管侵犯阳性的患者腹腔冲洗液中Reg IV 的表达水平明显升高（均为P=0.024）；晚期胃癌（Ⅲ期和Ⅳ期）患者腹腔冲洗液中Reg IV 的表达水平明显高于早期胃癌患者（I期和Ⅱ期）（P=0.015）。Reg IV 在胃癌患者中敏感性（100.0%）优于CA72-4（66.7%）和CK20（58.3%)。［结论］ Reg IV 的表达与胃癌的腹腔转移密切相关，利用荧光定量PCR检测胃癌患者的腹腔冲洗液中Reg IV 的水平，可以提高对胃癌腹腔转移的预测。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the correlation of the expression of Reg IV with peritoneal metastasis in gastric cancer. ［Methods］ The mRNA levels of Reg IV，CA72-4 and CK20 in peritoneal washing fluid in 50 Cases with gastric cancer were detected by real-time PCR. ［Results］ The expression of Reg IV in 12 cases with peritoneal metastasis(34.3，26.2~39.6) was significant higher than that in 38 cases without peritoneal metastasis(22.7，18.4~33.0) (P=0.017). The expression of Reg IV was closely correlated with lymph nodemetastasis and lymphatic vessel invasion (P=0.024); and also was higher in advanced stages than that in early stages (P=0.015). The sensitivity of Reg IV(100．０％) was higher than that of CA72-4 (66.7%) and CK20 (58.3%) for gastric cancer diagnosis. ［Conclusion］ The expression of Reg IV is closely related to peritoneal metastasis in gastric cancer. Detecting the expression of Reg IV from peritoneal washing fluid by RT-PCR could improve the predictability of peritoneal metastasis in gastric cancer. |
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