应莉莎,顾琳慧,杜灵彬.Reg IV与胃癌腹腔转移的相关性研究[J].肿瘤学杂志,2012,18(4):241-245.
Reg IV与胃癌腹腔转移的相关性研究
The Correlation of Reg IV with Peritoneal Metastasis in Gastric Cancer
投稿时间:2012-03-26  
DOI:
中文关键词:  胃肿瘤  Reg IV  CA72-4  CK20  腹腔转移
英文关键词:gastric neoplasms  Reg IV  CA72-4  CK20  peritoneal metastasis
基金项目:浙江省科技厅分析测试科技计划项目(2008F70024);浙江省医药卫生科技计划项目(2009B029)
作者单位
应莉莎 浙江省肿瘤研究所浙江省肿瘤医院 
顾琳慧 浙江省肿瘤研究所浙江省肿瘤医院 
杜灵彬 浙江省肿瘤研究所浙江省肿瘤医院 
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中文摘要:
      摘 要:[目的] 探讨Reg IV 表达与胃癌腹腔转移的相关性。[方法] 利用实时荧光定量PCR检测50例胃癌患者腹腔冲洗液中Reg IV、CA72-4、CK20 的表达水平。[结果] 病理诊断已明确发生腹腔转移的12例胃癌腹腔冲洗液中Reg IV的相对表达量为34.3(26.2~39.6),显著高于38例未发生腹腔转移的Reg IV的相对表达量22.7(18.4~33.0)(P=0.017)。Reg IV表达水平与患者淋巴结转移、淋巴管侵犯、临床分期等密切相关。淋巴结转移和淋巴管侵犯阳性的患者腹腔冲洗液中Reg IV 的表达水平明显升高(均为P=0.024);晚期胃癌(Ⅲ期和Ⅳ期)患者腹腔冲洗液中Reg IV 的表达水平明显高于早期胃癌患者(I期和Ⅱ期)(P=0.015)。Reg IV 在胃癌患者中敏感性(100.0%)优于CA72-4(66.7%)和CK20(58.3%)。[结论] Reg IV 的表达与胃癌的腹腔转移密切相关,利用荧光定量PCR检测胃癌患者的腹腔冲洗液中Reg IV 的水平,可以提高对胃癌腹腔转移的预测。
英文摘要:
      Abstract:[Purpose] To investigate the correlation of the expression of Reg IV with peritoneal metastasis in gastric cancer. [Methods] The mRNA levels of Reg IV,CA72-4 and CK20 in peritoneal washing fluid in 50 Cases with gastric cancer were detected by real-time PCR. [Results] The expression of Reg IV in 12 cases with peritoneal metastasis(34.3,26.2~39.6) was significant higher than that in 38 cases without peritoneal metastasis(22.7,18.4~33.0) (P=0.017). The expression of Reg IV was closely correlated with lymph nodemetastasis and lymphatic vessel invasion (P=0.024); and also was higher in advanced stages than that in early stages (P=0.015). The sensitivity of Reg IV(100.0%) was higher than that of CA72-4 (66.7%) and CK20 (58.3%) for gastric cancer diagnosis. [Conclusion] The expression of Reg IV is closely related to peritoneal metastasis in gastric cancer. Detecting the expression of Reg IV from peritoneal washing fluid by RT-PCR could improve the predictability of peritoneal metastasis in gastric cancer.
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