蒋佩佩,胡畅远,武文一.microRNA-212在胃癌中的表达及临床意义[J].肿瘤学杂志,2012,18(4):246-249.
microRNA-212在胃癌中的表达及临床意义
Expression of microRNA-212 in Gastric Cancer and Its Clinical Significance
投稿时间:2012-03-20  
DOI:10.11735/j.issn.1671-170X.2012.4.B2012116
中文关键词:  miRNA  miR-212  胃肿瘤
英文关键词:miRNA  miR-212  gastric neoplasms
基金项目:温州市科技局(H20100028)
作者单位
蒋佩佩 温州医学院附属第一医院 
胡畅远 温州医学院附属第一医院 
武文一 温州医学院附属第一医院 
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中文摘要:
      摘 要:[目的] 比较microRNA-212(miR-212)在胃癌组织和正常胃黏膜组织中的表达情况,并探讨其与临床病理特征之间的关系。[方法] 应用茎环RT-qPCR方法检测22例胃癌及癌旁正常胃黏膜组织标本中miR-212的表达。[结果] miR-212在胃癌及正常胃黏膜组织中的相对表达量分别为1.439和1.000,两者差异有统计学意义(P<0.05)。而且,胃癌组织中miR-212的表达与肿块位置、分化程度、淋巴结转移以及TNM分期有关(P<0.05)。[结论] miR-212的表达可能在胃癌发生发展过程中发挥重要作用。
英文摘要:
      Abstract:[Purpose] To investigate the expression of microRNA-212(miR-212) in gastric cancer and its relationship with clinicopathological characteristics. [Methods] The expression levels of miR-212 in 22 specimens of gastric carcinoma tissue and their matched non-tumor adjacent tissue specimens were examined by stem-loop real-time RT-PCR. [Results] The expression levels of miR-212 in gastric carcinoma tissue and normal gastric tissue were 1.439 and 1.000 respectively,with significant difference (P<0.05). Also,the expression levels of miR-212 related to the position of tumor,degree of differentiation,lymph node metastasis and TNM staging (P<0.05). [Conclusion] The expression of miR-212 might play a key role in the carcinogenesis and progress of gastric cancer.
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