| 蔡绍朋,岳喜成,李德群.TIP30与VEGF-C 在乳腺癌中的表达及意义[J].肿瘤学杂志,2012,18(6):408-412. |
| TIP30与VEGF-C 在乳腺癌中的表达及意义 |
| Expressions of TIP30 and VEGF-C in Breast Cancer and Their Significance |
| 投稿时间：2011-10-25 |
| DOI： |
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| 中文关键词: 乳腺肿瘤 转录反式作用因子结合蛋白 血管内皮生长因子-C 淋巴转移 |
| 英文关键词:breast neoplasms Tat-interacting protein 30 vascular endothelial growth factor-C lymphatic metastasis |
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| 中文摘要: |
| 摘 要：［目的］检测转录反式作用因子结合蛋白(TIP30)与血管内皮生长因子-C（VEGF-C)在乳腺癌中的表达水平。［方法］应用免疫组织化学Elivision法，检测72例乳腺癌及其癌旁乳腺组织中TIP30和VEGF-C蛋白表达水平，并分析它们与临床病理指标之间的关系。［结果］ TIP30蛋白在乳腺癌及相应的癌旁乳腺组织中的阳性表达率分别是33.33%、87.50%，两者之间差异有显著性（P<0.05）。VEGF-C蛋白在乳腺癌及相应的癌旁乳腺组织中的阳性表达率分别是80.56%、26.39%，两者之间差异有显著性（P<0.05）。TIP30蛋白、VEGF-C蛋白在乳腺癌的表达与有无淋巴结转移有关（P<0.05），而与患者年龄、临床分期、肿瘤大小、c-erbB-2和雌、孕激素受体表达均无关（P>0.05）。［结论］ TIP30在乳腺癌旁组织中的表达明显高于癌组织，VEGF-C表达情况则相反，两者呈负相关。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expressions of Tat-interacting protein 30 (TIP30) and vascular endothelial growth factor-C(VEGF-C) in breast cancer. ［Methods］ The expressions of TIP30 and VEGF-C in sample tissues from 72 cases with breast cancer and corresponding adjacent breast tissues were detected with Elivision immunohistochemical method， and their relationship with clinicopathologic parameters was analyzed.［Results］ The positive expression of TIP30 in breast cancer tissues and adjacent breast tissues were 33.33% and 87.50% respectively，with significant difference between them (P<0.05). The positive expression of VEGF-C in breast cancer tissues and adjacent breast tissues were 80.56% and 26.39% respectively， with significant differe-nce between them(P<0.05). The expressions of TIP30 and VEGF-C in breast cancer correlated to lymph node metastasis with or without(P<0.05)，but had not correlate to age， stage， tumor size， c-erbB-2， ER and PR (P>0.05).［Conclusion］ The expression of TIP30 in adjacent breast tissues is higher than that in breast cancer tissues， with a reverse expression of VEGF-C. There is a negative correlation between the expression of TIP30 and VEGF-C in breast cancer. |
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