| 毛伟敏,程 蕾.食管癌术后辅助治疗的Meta分析[J].肿瘤学杂志,2012,18(2):94-99. |
| 食管癌术后辅助治疗的Meta分析 |
| A Meta Analysis of Adjuvant Therapy for Esophageal Cancer Postoperation |
| 投稿时间：2011-12-06 |
| DOI： |
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| 中文关键词: 食管肿瘤 辅助化疗 辅助放疗 Meta分析 |
| 英文关键词:esophageal neoplasms adjuvant chemotherapy adjuvant radiation therapy Meta analysis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨食管癌术后辅助治疗的价值。［方法］ 收集1995年至2011年期间发表的关于食管癌术后辅助治疗的随机对照研究文章，利用Stata12.0软件进行Meta分析。［结果］ 与单纯手术相比，术后辅助化疗患者的3年无进展生存率相对危险度（RR）为1.225（95%CI:1.012~1.482，P=0.037 ），差异有统计学意义。而3、5年总生存率的RR值分别为0.899（95%CI：0.797～1.016，P=0.087）,1.183（95%CI：0.97～1.442，P=0.098），差异无统计学意义。同样，与单纯手术相比，术后辅助放疗患者的3年总生存率的RR值为0.935（95%CI： 0.879～0.994，P=0.033），差异有统计学意义。而5年总生存率的RR值为0.988（95%CI：0.821～1.188，P=0.897)，差异无统计学意义。Begg’s与Egger试验检测P值均大于0.05，不存在发表偏倚。［结论］ 术后辅助化疗能延长食管癌患者术后的3年无进展生存率，术后辅助放疗不利于延长食管癌患者的3年总生存率。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the value of adjuvant therapy for esophageal cancer postoperation.［Method］ randomized control study articles about adjuvant treatment after esophagectomy from 1995 to 2011 were collected，and Stata12.0 software was used for Meta analysis.［Reasults］ Compared with patients undergoing surgery alone，the 3-year progress free survival(PFS) in patients with adjuvant chemotherapy was significantly different，with RR 1.225(95%CI:1.012~1.482，P=0.037).But 3-，5-year overall survival rates(OS) with RR 0.899 (95%CI: 0.797~1.016，P=0.087) and 1.183 (95%CI:0.97~1.442，P=0.098)，respectively. 3-year OS of adjuvant radiation patients was significantly different with that of the patients with surgery alone，RR0.935 (95%CI:0.879~0.994，P=0.033).But 5-year OS with RR 0.988 (95%CI:0.821~ 1.188，P=0.897). P values of Begg’s and Egger test were greater than 0.05，indicating there was no publication bias in the study.［Conclusion］ Postoperative adjuvant chemotherapy can improve the 3-year PFS in patients with esophageal cancer after surgery，while postoperative adjuvant radiation does not improve 3-year OS. |
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