| 王 磊,翟嘉威,唐 末.微生物群滋养性免疫在结直肠癌发生发展中的作用[J].中国肿瘤,2022,31(3):221-227. |
| 微生物群滋养性免疫在结直肠癌发生发展中的作用 |
| The Role of Microbiota-nourishing Immunity in the Development of Colorectal Cancer |
| 投稿时间：2021-11-30 |
| DOI：10.11735/j.issn.1004-0242.2022.03.A009 |
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| 中文关键词: 微生物群滋养性免疫 微生物稳态 肠上皮完整 炎症微环境 宿主免疫 结直肠癌 |
| 英文关键词:microbiota-nourishing immunity microbial homeostasis intestinal epithelial integrity inflammatory microenvironment host immunity colorectal cancer |
| 基金项目:“十三五”重大疑难疾病中西医临床协作试点项目［国中医药办医政函（2018）275］；国家自然科学基金面上项目(82174461) |
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| 中文摘要: |
| 摘 要：微生物群滋养性免疫通过抑制肠道有害细菌、真菌的定植和异常扩张，在维持人体肠道微生物稳态、正常肠上皮细胞完整性及重塑宿主免疫系统中发挥了极其重要的作用。肠道微生物稳态的破坏及致病微生物的异常扩张所介导的炎症微环境及免疫功能异常已被反复证实与结直肠癌的发生发展具有紧密的联系。全文就微生物群滋养性免疫在抑制结直肠癌发生发展中的作用进行综述，并解释其中关键的作用机制。 |
| 英文摘要: |
| Abstract： By inhibiting the colonization and abnormal expansion of harmful bacteria and fungi in the intestinal tract， microbiota-nourishing immunity plays an important role in maintaining the homeostasis of human intestinal microorganisms， integrity of normal intestinal epithelial cells and remodeling the host immune system. The destruction of intestinal microbial homeostasis and abnormal expansion of pathogenic microorganisms mediated inflammatory microenvironment and immune dysfunction have been repeatedly confirmed to be closely related to the occurrence and development of colorectal cancer. In this paper， the contribution of microbiota-nourishing immunity in inhibiting the occurrence and development of colorectal cancer is reviewed， and the related mechanism is explained. |
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