| 何 美,李必波,杜 佳.2001—2018年重庆市肺癌患者临床特征及生存分析[J].中国肿瘤,2020,29(11):865-870. |
| 2001—2018年重庆市肺癌患者临床特征及生存分析 |
| Clinical Characteristics and Survival of Lung Cancer Patients in Chongqing，2001—2018 |
| 中文关键词 修订日期：2020-05-22 |
| DOI：10.11735/j.issn.1004-0242.2020.11.A013 |
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| 中文关键词: 肺癌 临床特征 生存率 重庆 |
| 英文关键词:lung cancer clinical characteristics survival rate Chongqing |
| 基金项目:重庆市科学技术局科研机构绩效激励引导专项(cstc2018jxjl130058)；重庆市技术创新与应用发展专项(cstc2019jscx?鄄fxydx0008)；重庆市卫生健康委重点疾病防治技术攻关专项(2019ZX002)；重庆市科卫联合课题面上项目(2019MSXM035) |
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| 中文摘要: |
| 摘 要：［目的］ 分析重庆市特殊病种医保中肺癌患者的生存情况，为肺癌防治提供参考依据。［方法］ 在全市恶性肿瘤特病系统中抽取2001—2018年的渝籍原发性肺癌患者作为研究对象，应用寿命表法计算生存率和中位生存期，并对相关人口学和临床信息进行分析，以反映重庆地区肺癌患者的生存状况。［结果］ 纳入分析的肺癌患者16 188例，平均年龄64.50岁，51.81%患者吸烟，11.20%患者有癌症家族史。总体5年生存率为24.81%，中位生存期为20个月。男性5年生存率（22.71%）低于女性（26.87%）；生存率随着年龄的增长、吸烟指数和临床期别的增加呈下降趋势，≤45岁组的5年生存率为39.62%，而 >75岁组仅为16.47%；不吸烟患者5年生存率为29.65%，吸烟指数≥400年支患者的5年生存率仅为21.52%；Ⅰ期患者5年生存率为62.72%，Ⅳ期仅为11.36%。不同病理类型患者生存率也存在差异，腺癌5年生存率最高（28.76%），其次为腺鳞癌（28.21%）、鳞癌（26.22%），最差的是小细胞癌（17.03%）。从总体来看，单纯手术者5年生存率（55.30%）最高，未手术者（17.14%）生存率最低。［结论］ 肺癌患者的预后较差，不同性别、年龄、病理类型、临床分期及治疗方案的患者生存率存在差异。控制吸烟、早期筛查、早期诊断、选择合适有效的治疗方式，是肺癌防控有效的手段。 |
| 英文摘要: |
| Abstract：［Purpose］To analyze the characteristics and survival of lung cancer patients in Chongqing municipality 2001—2008.［Methods］ The data of patients with primary lung cancer in Chongqing municipality during 2001 to 2018 were collected from Chongqing cancer registration system. Life table method was used to calculate survival rate and median survival time，and the related demographic characteristics and clinical information were analyzed. ［Results］There were 16 188 cases of lung cancer were included in the study. The average age of patients was 64.50 years，51.81% were smokers and 11.20% had family history of tumor. The overall 5-year survival rate was 24.81% and median survival time was 20 months. Survival rate was lower among males than that among females，with the 5-year survival of 22.71% and 26.87%，respectively. Survival rate decreased with the increasing of age，smoking index and clinical stage. Patients aged ≤45 years had a 5-year survival of 39.62%，while patients aged ≥75 years had a 5-year survival of 16.47%. Non-smoker patients had a 5-year survival of 29.65%，while patients smoking more than 400 cigarettes per year had a 5-year survival of 21.52%. Stage I patients had a 5-year survival of 62.72%，while those with stage IV had a 5-year survival of 11.36%. Survival of lung cancer patients differed by tumor histological subtypes. The 5-year survival of patients with adenocarcinoma(28.76%) was the highest，followed by those with adenosquamous carcinoma(28.21%)，squamous cell carcinoma(26.22%) and small cell lung cancer(17.03%). Overall，the survival rate of patients with surgical treatment was higher than that without surgery，with the 5-year survival of 55.30% and 17.14%，respectively.［Conclusion］The prognosis of lung cancer generally is poor. The survival rates are different with the different gender，age，pathological type，clinical stage and treatment. Effective measures for lung cancer prevention and control should be strengthened including tobacco control，early screening and early diagnosis，appropriate and effective treatment. |
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