| 毕春璐,姜青云,蔡 琴.腹腔热灌注联合手术及静脉化疗对Ⅱ、Ⅲ期结直肠癌疗效的Meta分析[J].中国肿瘤,2017,26(12):986-994. |
| 腹腔热灌注联合手术及静脉化疗对Ⅱ、Ⅲ期结直肠癌疗效的Meta分析 |
| Hyperthermic Intraperitoneal Chemotherapy Combined with Radical Resection and Intravenous Chemotherapy for StageⅡor Ⅲ Colorectal Cancer: A Meta-analysis |
| 投稿时间：2017-03-13 |
| DOI：10.11735/j.issn.1004-0242.2017.12.A012 |
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| 中文关键词: 结直肠肿瘤 腹腔热灌注 化学药物治疗 疗效 Meta分析 |
| 英文关键词:colorectal neoplasms hyperthermic intraperitoneal chemotherapy general chemotherapy efficacy Meta-analysis |
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| 中文摘要: |
| 摘 要：［目的］ 系统评价腹腔热灌注(HIPEC)联合直肠肿瘤根治术（CRR）及静脉化疗治疗Ⅱ、Ⅲ期结直肠癌的临床疗效。［方法］ 检索PubMed、EMbase、Cochrane Library、CBM、CNKI、万方数据，纳入国内外采用腹腔热灌注联合直肠肿瘤根治术及静脉化疗(CHC)对比结直肠肿瘤根治术联合静脉化疗（CC）治疗Ⅱ、Ⅲ期结直肠癌的随机对照试验（RCT），检索时限均为建库至2017年2月。采用RevMan 5.3 软件对纳入文献的1、2、3、5年生存率及2年局部复发率进行Meta 分析。［结果］ 最终纳入 11 个 RCT，共933例Ⅱ、Ⅲ期结直肠癌患者。CHC组2、3、5年生存率均优于CC组，两组1年生存率差异无统计学意义，其2年生存率OR为3.06（95%CI：1.54～6.11，P=0.001）；3年生存率OR为2.60（95%CI：1.76～3.83，P <0.00001）；5年生存率OR为2.37（95%CI：1.38～4.07，P=0.002）；1年生存率OR为1.51（95%CI：0.56～4.07，P=0.42）；CHC组2年局部复发率低于CC组，OR为0.20（95%CI：0.08～0.47，P=0.0002）。［结论］ 与CC模式相比，CHC模式可以有效提高Ⅱ、Ⅲ期结直肠癌患者的生存率，降低局部复发率。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the clinical efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) combined with radical resection and intravenous chemotherapy（CHC）in treatment of stage Ⅱ or Ⅲ colorectal cancer. ［Methods］ The databases CBM，CNKI，Wan Fang Data，PubMed，EMbase and the Cochrane Library from inception to February 2017 were searched for randomized controlled trials(RCTs) of HIPEC combined with radical resection and intravenous chemotherapy (CHC) versus radical resection with chemotherapy(CC) in treatment of stage Ⅱ or Ⅲ colorectal cancer. The 1-，2-，3-，5-year overall survival(OS) rate and the local recurrence rate of 2 years were analyzed. Meta-analysis was performed with Rev Man 5.3 software. ［Results］ Eleven RCTs involving 933 patients with stage Ⅱ or Ⅲ colorectal cancer were included. The 2-，3- and 5-year survival rates of CHC group were significantly higher than those of CC group： 2-year survival rate(OR=3.06， 95%CI：1.54~6.11，P=0.001)；3-year survival rate(OR=2.60，95%CI：1.76~3.83，P<0.00001)；4-year survival rate（OR=2.60，95%CI：1.76~3.83，P<0.00001）and 5-year survival rate(OR=2.37， 95%CI：1.38~4.07，P=0.002). However，there was no significant difference between the two groups in 1-year survival rate (OR=1.51，95%CI：0.56~4.07，P=0.42). The local recurrence rate of 2 years in CHC group was lower than that in CC group(OR=0.20，95%CI：0.08~0.47，P=0.0002). ［Conclusion］ Compared to the radical resection with chemotherapy，hyperthermal intraperitoneal chemotherapy combined with radical resection and intravenous chemotherapy can improve the survival of patients with stage Ⅱ or Ⅲ colorectal cancer and reduce the local recurrence. |
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