| 徐 超,姚庆华.肠道菌群与结直肠癌的研究进展[J].中国肿瘤,2016,25(8):634-638. |
| 肠道菌群与结直肠癌的研究进展 |
| Research Progress in Relationship between Gut Microbiota and Colorectal Cancer |
| 投稿时间：2015-11-24 |
| DOI：10.11735/j.issn.1004-0242.2016.08.A011 |
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| 中文关键词: 肠道细菌屏障 结直肠肿瘤 益生菌 凋亡 |
| 英文关键词:gut bacteria barrier colorectal cancer gut probiotic microbiota apoptosis |
| 基金项目:浙江省自然科学基金（Q12H160028） |
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| 摘要点击次数: 2535 |
| 全文下载次数: 642 |
| 中文摘要: |
| 摘 要：肠道细菌屏障即肠黏膜生物屏障及肠道益生菌的功能与临床多种疾病的成因和治疗有着紧密的联系，如炎症性肠病、肝硬化、肿瘤等。肠道细菌屏障及肠道益生菌能够通过协同免疫屏障、机械屏障对肿瘤起杀伤作用，并可分泌相关生化产物对抑制肿瘤生成，同时可以促进肿瘤细胞的凋亡，改善肠道肿瘤微环境。全文结合最近国内外的研究状况对肠道细菌屏障及益生菌与肿瘤之间的关系作一综述。 |
| 英文摘要: |
| Abstract：The function of gut bacteria barrier also known as gut biological barrier and gut probiotic microbiota is associated with the pathogenesis and therapy of disease，for instance，inflammatory bowel disease，cirrhosis，colorectal cancer. Gut bacteria barrier cooperated with immune barrier and physiological barrier induces the apoptosis of colorectal cancer cells，meanwhile secretes a lot of cytokines to inhibit the generation of colorectal cancer cells which can improve the tumor microenvironment. This article reviews research on the relationship between gut probiotic microbiota and colorectal cancer. |
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