王 晨,杨红健,凌志强.MicroRNA在雌激素受体阳性乳腺癌中的研究进展[J].中国肿瘤,2016,25(4):286-289. |
MicroRNA在雌激素受体阳性乳腺癌中的研究进展 |
Research Progress in microRNA in Estrogen Receptor Positive Breast Cancer |
投稿时间:2015-09-22 |
DOI:10.11735/j.issn.1004-0242.2016.04.A009 |
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中文关键词: microRNA 乳腺癌 雌激素受体 雌激素 |
英文关键词:microRNA breast cancer estrogen receptor estradiol |
基金项目:浙江省自然科学基金面上项目(LY12H16030),浙江省医药卫生科技计划项目(2011RCA015),浙江省中医药科学研究基金项目(2011ZA016) |
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中文摘要: |
摘 要:MicroRNA(miRNA)能调节细胞生长、增殖、分化和凋亡等活动,与各种恶性肿瘤的发生发展息息相关,乳腺癌亦不例外。在乳腺癌中,雌激素受体(ER)阳性者占有相当大的比例,约75%,因此雌二醇(E2)、ER与miRNA的相互联系以及相互调节机制需予以重视,进而有助于探索miRNA对ER阳性乳腺癌的临床应用价值。全文就近年来的相关研究成果加以概述和总结,旨在为转化医学提供信息,将相关研究成果应用于临床。 |
英文摘要: |
Abstract:microRNA(miRNA) regulates the growth,proliferation,differentiation and apoptosis of cells,which plays significantly important role in all kinds of tumors,and breast cancer is no exception. According to the molecular classification of breast cancer,the estrogen receptor (ER) positive subtype approximately accounts for 75%. As this subtype is major,the relationship and mechanism between estradiol(E2),ER and miRNA should be paid more attention to. So that we can further study the clinical value of miRNA in ER positive breast cancer. This article summarizes the current studies,aims to give some useful information from relevant researches to clinic. |
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