| 黄显聪,凌志强,毛伟敏.RNF180在肿瘤中的作用机制及临床应用研究进展[J].中国肿瘤,2016,25(1):48-50. |
| RNF180在肿瘤中的作用机制及临床应用研究进展 |
| Research Progress of Mechanism and Clinical Application of RNF180 in Tumor |
| 投稿时间：2015-06-02 |
| DOI：10.11735/j.issn.1004-0242.2016.01.A009 |
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| 中文关键词: RNF180 肿瘤 甲基化 预后 |
| 英文关键词:RNF180 neoplasms methylation prognostic |
| 基金项目:国家自然科学基金资助项目（81172081），浙江省科技重大专项（2011C13039-1） |
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| 中文摘要: |
| 摘 要：RNF180是一种新型的环指基因编码蛋白，作为E3泛素蛋白连接酶参与细胞分化、增殖、各种疾病和肿瘤的发生等各种生物过程。RNF180抑癌基因通过甲基化沉默或下调基因表达，与肿瘤的发生及发展密切相关。已有相关研究表明，RNF180基因的甲基化程度及其CpG甲基化位点与肿瘤患者生存显著相关，在临床中可作为独立的预后因子。 |
| 英文摘要: |
| Abstract：RNF180，a novel RING finger gene-encoded product，as a E3 ubiquitin protein ligase participates in most cellular processes such as differentiation，proliferation，disorders and tumorigenesis. RNF180 is an anti-oncogene，and its expression in cancers is silenced or downregulated through methylation，which is closely related to the occurrence and carcinogenesis of tumor. Some related studies has indicated that the methylation degree of RNF180 gene and its CpG methylation site were significantly correlated with tumor survival，which could be considered as independent prognostic factors in clinic. |
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