| 蔡有余,艾 真,孙海岚.活性乳清蛋白因子在恶性肿瘤治疗中的应用进展[J].中国肿瘤,2015,24(12):1026-1030. |
| 活性乳清蛋白因子在恶性肿瘤治疗中的应用进展 |
| Progress in Application of Whey Protein Concentrate in the Treatment for Malignancies |
| 投稿时间：2015-08-11 |
| DOI：10.11735/j.issn.1004-0242.2015.12.A015 |
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| 中文关键词: 乳清蛋白 谷胱甘肽 肿瘤 营养治疗 |
| 英文关键词:whey protein glutathione tumor nutrition therapy |
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| 摘要点击次数: 1941 |
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| 中文摘要: |
| 摘 要：活性乳清蛋白因子（whey protein concentrate，WPC）作为安全有效的半胱氨酸载体，可有效促进机体谷胱甘肽合成，从而升高血清和组织中谷胱甘肽水平以及增强淋巴细胞增殖、吞噬作用和T辅助细胞和细胞毒性T细胞的天然杀伤活性，改善免疫力低下状态；同时WPC作为优质氮源能改善患者负氮平衡，能刺激肌肉蛋白质的合成，以避免或减缓发展到恶病质和由此产生的不良反应。在恶性肿瘤患者综合抗肿瘤治疗过程中，联合或强化应用活性乳清蛋白因子可以改善患者的营养和免疫状态。 |
| 英文摘要: |
| Abstract：As a safe and effective cysteine carrier，whey protein concentrate(WPC) effectively promote the body’s glutathione synthesis，thereby elevating glutathione level in serum and tissue and enhancing lymphocyte proliferation and phagocytosis，as well as T helper cells and cytotoxic activity of natural killer T cells，which finally improve the immune system. Second，as quality nitrogen source，WPC significantly improve the negative nitrogen balance of patients，stimulate muscle protein synthesis to avoid or slow down the development of the cachexia and the resulting adverse reactions. During the process of the integrated anti-tumor treatment，the application of whey protein concentrates for malignancies may improve the patients nutritional and immune status，reduce the stress reaction of anti-tumor treatments(surgery，radiation and chemotherapy)， and reduce the risk of infectious complications，as well as prevent or slow down smooth muscle loss and improve the quality of life. |
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